2011 Fiscal Year Final Research Report
Evaluation of hemodynamic changes in pulmonary and systemic arterial circulation with special attention to shunt volume in patients with pulmonary fibrosis using phase contrast MRI.
| Project/Area Number |
21591570
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAKINOHANA Yasumasa 琉球大学, 大学院・医学研究科, 助教 (20185713)
KAMIYA Hisashi 琉球大学, 大学院・医学研究科, 助教 (60363678)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 肺高血圧 / MRI / Velocity-encoded cine MRI / 肺動脈血流 |
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| Research Abstract |
Using PC-MRI, we calculated various indexes of the pulmonary blood flow of the patients that pulmonary hypertension should have been suspected and examined correlation with the echocardiographic tricuspid gradient. As a result, an average area of the pulmonary artery truncus, minimum area, and a maximal area a were well correlated with tricuspid gradient. It was minimum area to have been the strongest in a correlation ;(coefficient of correlation 0. 772 ; p=0. 001). Secondly, an aortic and pulmonary arterial flow by PC-MRI for normal volunteers and patients with interstitial pneumonia were calculated both during free breathing and respiratory breath-holding. Both flow significantly decreased in normal volunteers and patients. However, in patients, no significant reduction under the breath-holding nor increase of bronchopulmonary shunt were observed.
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