Imaging of proliferative ability and hypoxia of tumor in radioimmunotherapy

2012 Fiscal Year Final Research Report

• Project/Area Number: 21591580
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kinki University
• Principal Investigator: HOSONO Makoto 近畿大学, 医学部附属病院, 教授 (00281303)
• Project Period (FY): 2009 – 2012
• Keywords: 放射免疫療法 / 低酸素 / 悪性リンパ腫 / 抗原抗体 / 陽電子断層撮影

Research Abstract

In patients with CD20 positive B-cell non-Hodgkin lymphoma who underwent yttrium-90 labeled anti-CD20 ibritumomab tiuxetan therapy, glucose metabolism by FDG and hypoxia by FMISO were evaluated with PET/CT before and after therapy, and changes were analyzed over time. Antigen expression of CD20 was also evaluated by SPECT/CT using indium-111 labeled anti-CD20 antibody. Association of glucose metabolism, hypoxia, and CD20 expression with therapeutic response was analyzed.

Research Products

• [Journal Article] Dynamic sequence respiratory gated perfusion pulmonary SPECT without external tracking device (2013)
  • Author(s): Sakaguchi K, Hosono M, Otsuka M, Hanaoka K, Usami K, Uto T, Ishii K
  • Journal Title: Ann Nucl Med Volume: 27(1) Pages: 65-73
  • Peer Reviewed
• [Journal Article] A Prospective Clinical Trial of Tumor Hypoxia Imaging with 18F-fluoromisonidazole Positron Emission Tomography and Computed Tomography (F-MISO PET/CT) before and during Radiation Therapy (2013)
  • Author(s): Tachibana I, Nishimura Y, Shibata T, Kanamori S, Nakamatsu K, Koike R, Nishikawa T, Ishikawa K, Tamura M, Hosono M
  • Journal Title: J Radiation Research Volume: (in press)
  • Peer Reviewed
• [Journal Article] The iliac wing sign: an indicator of the presence of bone and/or soft-tissue injury of the pelvis and hips (2012)
  • Author(s): Kakigi T, Hosono M, Taro Shimono T, Hiraoka T, Nishimura K
  • Journal Title: European Journal of Radiology Volume: 81 Pages: 2348-2352
  • Peer Reviewed
• [Journal Article] Impact of CT attenuation correction by SPECT/CT in brain perfusion images (2012)
  • Author(s): Ishii K, Hanaoka K, Okada M, Kumano S, Komeya Y, Tsuchiya N, Hosono M, Murakami T
  • Journal Title: Ann Nucl Med Volume: 26(3) Pages: 241-247
  • Peer Reviewed
• [Journal Article] Recognition of complete response by long-term observation after treatment with 90Y-Ibritumomab tiuxetan for relapsed follicular lymphoma (2012)
  • Author(s): Tatsumi Y, Rai S, Shimada T, Yamaguchi K, Morita Y, Kawanishi K, Miyatake J, Ashida T, Hosono M, Matsumura I
  • Journal Title: Acta Med Kinki Univ Volume: 36(2) Pages: 87-89
  • Peer Reviewed
• [Journal Article] FDG uptake in bone marrow after G-CSF administration in patients with non-Hodgkin lymphoma (2011)
  • Author(s): Hanaoka K, Hosono M, Tatsumi Y, 6) Komeya Y, Tsuchiya N, Usami K, Yuzuru Y, Ishii K, Sumita M
  • Journal Title: Nucl Med Commun Volume: 32(8) Pages: 678-683
  • Peer Reviewed
• [Journal Article] Fourth ventricular mixed germ cell tumor demonstrating adipose tissue in a young adult (2010)
  • Author(s): Kuriu A, Shimono T, Kuwabara M, Ashikaga R, Hosono M, Murakami T
  • Journal Title: Jpn J Radiol Volume: 28 Pages: 166-168
  • Peer Reviewed
• [Journal Article] Radiation treatment planning using positron emission and computed tomography for lung pharyngeal cancers: a multiple-threshold method for [18F]fluoro-2-deoxyglucose activity (2010)
  • Author(s): Okubo M, Nishimura Y, Nakamatsu K, Okumura M, Shibata T, Kanamori S, Hanaoka K, Hosono M
  • Journal Title: Int J Radiation Oncology Biol Phys Volume: 77:2 Pages: 350-356
  • Peer Reviewed
• [Journal Article] FDG PET/CT versus CT, MR imaging, and 67Ga scintigraphy in the posttherapy evaluation of malignant lymphoma (2010)
  • Author(s): Okada M, Sato N, Ishii K, Matsumura K, Hosono M, Murakami T
  • Journal Title: Radiographics Volume: 30(4) Pages: 939-57
  • Peer Reviewed
• [Journal Article] Decreased brain FDG uptake in patients with extensive non-Hodgkin's lymphoma lesions (2010)
  • Author(s): Hanaoka K, Hosono M, Shimono T, Usami K, Komeya Y, Tsuchiya N, Yamazoe Y, Ishii K, Tatsumi Y, Sumita M
  • Journal Title: Ann Nucl Med Volume: 24 Pages: 707-711
  • Peer Reviewed
• [Journal Article] Demonstration of cerebellar atrophy in neuroacanthocytosis of 2 siblings (2009)
  • Author(s): Katsube T, Shimono T, Ashikaga R, Hosono M, Kitagaki H, Murakami T
  • Journal Title: AJNR Am J Neuroradiol Volume: 30: 2 Pages: 386-8
  • Peer Reviewed
• [Journal Article] Integrated FDG-PET/CT compared with intravenous contrast enhanced CT for evaluation of metastatic regional lymph nodes in patients with resectable early stage esophageal cancer (2009)
  • Author(s): Okada M, Murakami T, Kumano S, Kuwabara M, Shimono T, Hosono M, Shiozaki H
  • Journal Title: Ann Nucl Med Volume: 23:1 Pages: 73-80
  • Peer Reviewed
• [Journal Article] Ring-shaped lateral ventricular nodules: an incidental finding on brain magnetic resonance imaging (2009)
  • Author(s): Shimono T, Hosono M, Ashikaga R, Kumano S, Imaoka I, Yagyu Y, Okada M, Kuwabara M, Murakami T
  • Journal Title: Neuroradiology Volume: 51:3 Pages: 145-150
  • Peer Reviewed
• [Journal Article] Adrenal masses: the value of additional fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) in differentiating between benign and malignant lesions (2009)
  • Author(s): Okada M, Shimono T, Komeya Y, Ando R, Kagawa Y, Katsube T, Kuwabara M, Yagyu Y, Kumano S, Imaoka I, Tsuchiya N, Ashikaga R, Hosono M, Murakami T
  • Journal Title: Ann Nucl Med Volume: 23(4) Pages: 349-354
  • Peer Reviewed
• [Presentation] Prediction of tumor response by Indium-111-Zevalin SPECT/CT and FDG-PET/CT in radioimmunotherapy for B-cell non-Hodgkin lymphoma (2012)
  • Author(s): Hosono M, Hanaoka K, Ishii K, Sakaguchi K, Im S, Tsuchiya N, Komeya Y, Yagyu Y, Tatsumi Y, Matsumura I
  • Organizer: Annual Congress of European Association of Nuclear Medicine
  • Place of Presentation: Milan, Italy
  • Year and Date: 20121027-31
• [Presentation] Three dimensional planning of radioiodine therapy for hyperthyroidism by iodine-123 SPECT/CT (2012)
  • Author(s): Hanaoka K, Hosono M, Kurokawa T, Sakaguchi K, Yoshida S, Inoue R, Ishii K, Murakami T
  • Organizer: Annual Congress of European Association of Nuclear Medicine
  • Place of Presentation: Milan, Italy
  • Year and Date: 20121027-31
• [Presentation] Indium-111-Zevalin-SPECT/CT and FDG-PET/CT as quantitative evaluation in radioimmunotherapy for B-cell non-Hodgkin's lymphoma (Abstract: P706) (2011)
  • Author(s): Hanaoka K, Hosono M, Yamazoe Y, Tatsumi Y, Komeya Y, Tsuchiya N, Ishii K, Usami K, Murakami T, Uto T
  • Organizer: EANM' 11 annual congress of European Society of Nuclear Medicine
  • Place of Presentation: Birmingham, UK
  • Year and Date: 20111015-19
• [Presentation] Measurement of functional thyroid weight using I-123 SPECT/CT as planning for radioiodine therapy (Abstract: PW034) (2011)
  • Author(s): Hanaoka K, Hosono M, Shimosegawa E, Hatazawa J
  • Organizer: EANM' 11 annual congress of European Society of Nuclear Medicine
  • Place of Presentation: Birmingham, UK
  • Year and Date: 20111015-19
• [Presentation] A prospective Clinical Trial on Tumor Hypoxia Imaging with 18F-misonidazole (F-MISO) positron Emission Tomography (PET) (2011)
  • Author(s): Tachibana I, Nishimura Y, Shibata T, Kanamori S, Nakamatsu K, Tamura M, Koike R, Nishikawa T, Ishikawa K, Hosono M
  • Organizer: 53rd annual meeting of ASTRO
  • Place of Presentation: Miami, Florida, USA
  • Year and Date: 20111002-06
• [Presentation] The iliac wing sign: The feasibility for diagnosis of bone and/or soft-tissue injury of the pelvis and hips (2011)
  • Author(s): Kakigi T, Hosono M, Shimono T, Hiraoka T, Nishimura K
  • Organizer: ECR 2011
  • Place of Presentation: Vienna, Austria
  • Year and Date: 20110303-07
• [Presentation] FDG uptake in bone marrow after G-CSF administration in patients with non-Hodgkin lymphoma (2010)
  • Author(s): Hanaoka K, Hosono M, Komeya Y, Tsuchiya N, Usami k, Yamazoe Y, Ishii K, Tatsumi Y, Murakami T
  • Organizer: Abstract#P502, EANM'10
  • Place of Presentation: Vienna, Austria
  • Year and Date: 20101009-13
• [Presentation] Indium-111-Zevalin and FDG uptake in association with tumor response in radioimmunotherapy for B-cell non-Hodgkin's lymphoma (2010)
  • Author(s): Hanaoka K, Hosono M, Yamazoe Y, Komeya Y, Tsuchiya N, Usami K, Sumita M, Tatsumi Y
  • Organizer: Abstract#P726, EANM'10
  • Place of Presentation: Vienna, Austria
  • Year and Date: 20101009-13
• [Presentation] Definition of target volumes by PET/CT for radiation therapy planning using moving phantom (2010)
  • Author(s): Hanaoka K, Hosono M, Okubo M, Usami K, Okumura M, Sumita M, Nishimura Y, Murakami T
  • Organizer: Abstract#TP10, EANM'10
  • Place of Presentation: Vienna, Austria
  • Year and Date: 20101009-13
• [Presentation] Measurement of regional cerebral blood flow associated with cilostazol therapy in vascular dementia (2009)
  • Author(s): Hanada K, Hosono M, Hitomi Y, Tsuchiya N, Komeya Y, Tsujii N, Kitahata D, Takahashi E, Murakami T
  • Organizer: 56th annual meeting of Society of Nuclear Medicine
  • Place of Presentation: Toronto, Canada
  • Year and Date: 20090613-17
• [Presentation] Assessment of lymph node metastasis esophageal cancer with SUV correction based on count recovery on 18F-FDG (2009)
  • Author(s): Komeya Y, Hosono M, Tsuchiya N, Okada M, Kagawa Y, Hanaoka K, Usami K, Yamazoe Y, Murakami T, Itoh T
  • Organizer: 56th annual meeting of Society of Nuclear Medicine
  • Place of Presentation: Toronto, Canada
  • Year and Date: 20090613-17
• [Presentation] Decreased brain FDG uptake in patients with FDG-avid non-Hodgkin lymphoma lesions (2009)
  • Author(s): Hanaoka K, Hosono M, Shimono T, Komeya Y, Tsuchiya N, Usami K, Yamazoe Y, Sumita M, Itoh T
  • Organizer: 56th annual meeting of Society of Nuclear Medicine
  • Place of Presentation: Toronto, Canada
  • Year and Date: 20090613-17
• [Presentation] FDG uptake in bone marrow after G-CSF administration in patients with non-Hodgkin lymphoma (2009)
  • Author(s): Hanaoka K, Hosono M, Komeya Y, Tsuchiya N, Ohata A, Usami K, Yamazoe Y, Sumita M, Itoh T
  • Organizer: 56th annual meeting of Society of Nuclear Medicine
  • Place of Presentation: Toronto, Canada
  • Year and Date: 20090613-17
• [Presentation] Characteristics of FDG biodistribution in chronic hemodialysis patients (2009)
  • Author(s): Hanaoka K, Hosono M, Komeya Y, Ohata A, Usami K, Tsuchiya N, Yamazoe Y, Sumita M, Shimono T, Itoh T
  • Organizer: 56th annual meeting of Society of Nuclear Medicine
  • Place of Presentation: Toronto, Canada
  • Year and Date: 20090613-17
• [Book] 医療放射線の安全確保と有効利用に関する研究・主任研究者総括報告書 厚生労働科学研究費補助金研究報告書 (2012)
  • Author(s): 細野 眞
• [Book] 医療放射線の安全確保と有効利用に関する研究・主任研究者総括報告書 厚生労働科学研究費補助金研究報告書(平成23年度) (2012)
  • Author(s): 細野 眞
• [Book] 中長期的に展望する医療放射線の安 全規制に関する課題 厚生労働科学研究費補助金研究報告書(平成23年度) (2012)
  • Author(s): 細野 眞、藤村洋子、堀越亜希子、柳田 幸子
• [Book] 切除不能肝癌の治療に用いられるイ ットリウム-90 樹脂微小球体の有効性と投与された患者の管理区域からの退出などの放射線防護対策について 厚生労働科学研究 費補助金研究報告書(平成23年度) (2012)
  • Author(s): 細野 眞、米矢吉宏、宇佐美公男、花岡 宏平、池渕秀治、中村吉秀、中村伸貴、柳田 幸子、山田崇裕、北岡麻美、小島清孝、菅野 宏泰
• [Book] PET-CT、PET-MRI 及びSPECT-CT 検査における放射線の安全確保に関する検討 厚生労働科学研究費補助金研究報告書(平成23年度) (2012)
  • Author(s): 細野 眞、米矢吉宏、宇佐美公男、花岡 宏平、池渕秀治、中村吉秀、中村伸貴、柳田 幸子、山田崇裕、北岡麻美
• [Book] 核医学治療(RI内用療法)における放射線安全の確保に関する検討 厚生労働科学研究費補助金研究報告書(平成23年度) (2012)
  • Author(s): 米矢吉宏、細野 眞、宇佐美公男、花岡 宏平、池渕秀治、中村吉秀、中村伸貴、柳田 幸子、山田崇裕、北岡麻美
• [Book] 厚生労働科学研究費補助金研究報告書(平成23年度) (2012)
  • Author(s): 核医学治療(RI 内用療法)における放射線安全の確保に関する検討
• [Book] 放射性同位元素内用療法162-165 臨床放射線腫瘍学(編集日本放射線腫瘍学会・日本放射線腫瘍学研究機構) (2012)
  • Author(s): 細野 眞
  • Publisher: 南江堂
• [Book] FDG PET PET/CT 診療ガイドライン2012 (2012)
  • Author(s): 細野 眞
  • Total Pages: 391-401
  • Publisher: 核医学
• [Book] Gamut of FDG-PET (2012)
  • Author(s): 御前 隆、石津浩一、石守崇好、工藤崇、中本 裕士、東 達也、細野 眞
  • Total Pages: 357-389
  • Publisher: 核医学
• [Book] 医療放射線の安全確保と有効利用に関する研究・主任研究者総括報告書 厚生労働科学研究費補助金研究報告書(平成22年度) (2011)
  • Author(s): 細野 眞
• [Book] 中長期的に展望する医療放射線の安全規制に関する課題 厚生労働科学研究費補助金研究報告書(平成22年度) (2011)
  • Author(s): 細野 眞 藤村洋子、堀越亜希子
• [Book] PET 第3版今日の消化器疾患 治療指針 (2010)
  • Author(s): 細野 眞
  • Total Pages: 150-153
  • Publisher: 医学書院
• [Book] 医療放射線の安全確保に関する研究・主任研究者総括報告書 厚生労働科 学研究費補助金研究報告書(平成21年度) (2010)
  • Author(s): 細野 眞
• [Book] 中長期的に展望する医療放射線の安全規制に関する課題 厚生労働科学研究費 補助金研究報告書(平成21年度) (2010)
  • Author(s): 細野 眞 並木宣雄、藤村洋子、堀越亜 希子
• [Book] エックス線診療線量の測定とその全国実施の手法に関する課題 厚生労働科学研究費補助 金研究報告書(平成21年度) (2010)
  • Author(s): 宇佐美公男、細野 眞、米矢吉宏、白石 美保、松本圭一、池渕秀治、中村吉秀、柳田 幸子、中村伸貴、吉田浩一、福田光道
• [Remarks]
  • URL: http://positron.me