2011 Fiscal Year Final Research Report
Studies about gimeracil, a radiosensitizer
| Project/Area Number |
21591616
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 放射線治療 |
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| Research Abstract |
We studied the radiosensitizing effects of gimeracil, a component of TS-1, an anti-cancer drug. We obtained the following results. Gimeracil had the radiosensitizing effects in all different 10 cells examined. Gimeracil did not influence the cell cycle. Gimeracil partially inhibited the homologous recombination repair(HR) of DNA double strand breaks. dihydropyrimidine dehydrogenase(DPYD) is the target protein for radiosensitization by Gimeracil. The inhibitors of DPYD such as Gimeracil could enhance the efficacy of radiotherapy through partial suppression of HR-mediated DNA repair.
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[Journal Article] Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination2011
Author(s)
Sakata K, Someya M, Matsumoto Y, Tauchi H, Kai M, Toyota M, Takagi M, Hareyama M, Fukushima M
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Journal Title
Cancer Sci
Volume: 102(9)
Pages: 1712-1716
Peer Reviewed
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