2011 Fiscal Year Final Research Report
Effects of Sivelestat Sodium Hydrate on the prevention of lethal radiation induced lung damage
| Project/Area Number |
21591621
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Masatsugu 大阪医科大学, 医学部, 講師 (00330077)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 好中球エラスターゼ阻害剤 / シベレスタットナトリウム水和剤 / 放射線肺臓炎 / 肺線維症 |
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| Research Abstract |
Twelve-week-old female C57BL/6J mice were used. Neutrophil elastase inhibitor(Sivelestat Sodium Hydrate) was administered just before irradaiation and 1 hr., 3 hrs., and 6 hrs. after delivering a dose of 20 Gy to the whole lung in a single fraction. Neutrophil elastase inhibitor prevented and reduced severe acute lung damage which sometimes jeopardize the patient's life and improved the survival rate. Histopathological study proved that it also reduced the lung fibrosis followed by the acute lung damage. Neutrophil elastase inhibitor has promising effects on the reduction of the lung injury caused by radiation therapy.
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