2011 Fiscal Year Final Research Report
Suppression of induction and accumulation at tumor site of regulatory T cells by inhibition of VEGF/VEGFR2 pathway
| Project/Area Number |
21591670
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
MORISAKI Takashi 九州大学, 大学院・医学研究院, 共同研究員 (90291517)
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| Co-Investigator(Kenkyū-buntansha) |
KATANO Mitsuo 九州大学, 大学院・医学研究院, 教授 (10145203)
KUBO Makoto 九州大学, 大学病院, 助教 (60403961)
ONISHI Hideya 九州大学, 大学院・医学研究院, 准教授 (30553276)
NAKAMURA Katsuya 九州大学, 大学病院, 助教 (60585743)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 制御性T細胞 / VEGFR2 / VEGF / 腫瘍内集積 / 遊走 / 予後因子 |
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| Research Abstract |
Regulatory T cells(Treg cells) is one of negative regulators in human immune system. Thus, it is supposed that tumor tissue-infiltrating Treg cells suppress the anti-tumor immunity at the tumor site. If so, suppression of accumulation of Treg cells into the tumor tissue may improve the antitumor immunity. However, only a few therapeutic target molecules for regulating Treg cells are available at present. We showed that vascular endothelial growth factor receptor2(VEGFR2) is a useful therapeutic target against Treg cells. During this research periods, we acquired following new findings.(1) VEGFR2 is selectively expressed on highly-suppressive(FOXP3high) Treg cells.(2) The number of VEGFR2-positive Treg cells is more rich in cancer tissues than in peripheral blood.(3) Chemotactic migration of VEGFR2-positive Treg cells against VEGF is suppressed by addition of an anti-VEGF antibody, Avastin.(4) The number of VEGFR2-positive Treg cells at the tumor site is an independent poor prognostic factor in the colon cancer. These data indicate that VEGFR2-positive Treg cells regulate negatively the antitumor immunity and that VEGF/VEGFR2 pathway may be a useful therapeutic target for improving tumor immunity.
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[Journal Article] The contribution of vascular endothelial growth factor to the induction of regulatory T-cells in malignant effusions2009
Author(s)
Wada J, Suzuki H, Fuchino R, Yamasaki A, Nagai S, Yanai K, Koga K, Nakamura M, Tanaka M, Morisaki T, Katano M.
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Journal Title
Anticancer Research
Volume: 29
Pages: 881-888
Peer Reviewed
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