2011 Fiscal Year Final Research Report
The elucidation of mechanisms for Collagen Type Vα3 chains anti-organ adhesion function and there application.
| Project/Area Number |
21591672
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Tokai University (2010-2011)
Oita University (2009) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
INAGAKI Yutaka 東海大学, 医学部, 教授 (80193548)
MATSUO Noritaka 大分大学, 医学部, 准教授 (10284788)
YOSHIOKA Hidekatsu 大分大学, 医学部, 教授 (00222430)
HAMANAKA Ryouji 大分大学, 医学部, 助教 (60274750)
OKAMOTO Osamu 大分大学, 医学部, 講師 (40284799)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 実験外科学 / 癒着防止 / 抗線維化 / V型コラーゲンα3鎖 |
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| Research Abstract |
Organ adhesion were one case of excess tissue fibrosis caused wound healing after operation. Organ adhesion has bad influences for functional recovery and patients QOL. In this study elucidated that, minor component of collagen Type Vα3 chain(α3(V)) has anti tissue adhesion and fibrosis activity and specific expression in early time wound tissue. Inα3(V) rich regions collagen fiber observed thin and soft shapes. The idea forα3(V) anti-fibrosis activity were inhibited collagen banding step directly for any data from this study.α3(V) could very promising material for organ adhesion blocking treatment.
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Research Products
(15 results)
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[Journal Article] Long-term administration of the fungus toxin, sterigmatocystin, induces intestinal metaplasia and increases the proliferative activity of PCNA, p53, and MDM2 in the gastric mucosa of aged Mongolian gerbils2011
Author(s)
Kusunoki M., Misumi J., Shimada T., Aoki K., Matsuo N., Sumiyoshi H., Yamaguchi T. and Yoshioka H.
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Journal Title
Environ Health Prev. Med.
Volume: 16(4)
Pages: 224-231
Peer Reviewed
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