2011 Fiscal Year Final Research Report
Cooperation of cancer stem cell properties and epithelial-Mesenchymal transition in chemosensitivity in breast cancer
| Project/Area Number |
21591677
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHIDA Tetsu 慶應義塾大学, 医学部, 助教 (80327543)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 癌幹細胞 / EMT / 化学療法感受性 / PSK / 乳癌 |
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| Research Abstract |
We recently screened for novel TGF-b inhibitors among commercially available drugs and identified PSK as a strong inhibitor of the TGF-β-induced reporter activity of 3TP-lux. PSK suppressed TGF-β1-induced EMT, and FACS analysis showed that PSK inhibited the EMT-mediated generation of CD44+/CD24-cells.
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