Clinical research of CD24 expression and the importance on tumor progression.

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591691
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Dokkyo Medical University
• Principal Investigator: KATO Hiroyuki 獨協医科大学, 医学部, 教授 (70224532)
• Co-Investigator(Kenkyū-buntansha): YODA Norihito 獨協医科大学, 医学部, 講師 (40383038) ; TSUBAKI Masahiro 獨協医科大学, 医学部, 准教授 (70306158) ; SASAKI Kinro 獨協医科大学, 医学部, 准教授 (50245099) ; FUJITA Masanori 獨協医科大学, 医学部, 講師 (30383037) ; NAKAJIMA Masanobu 獨協医科大学, 医学部, 講師 (40451710) ; TAKAHASHI Masakazu 獨協医科大学, 医学部, 助教
• Co-Investigator(Renkei-kenkyūsha): SOHDA Makoto 国立大学法人群馬大学, 医学部, 助教 (70507326) ; ASAO Takayuki 国立大学法人群馬大学, 医学部, 准教授 (40212469) ; SANO Akihiko 国立大学法人群馬大学, 医学部, 医員 (20431702) ; KUWANO Hiroyuki 国立大学法人群馬大学, 医学部, 教授 (90186560) ; TANAKA Naritake 国立大学法人群馬大学, 医学部, 助教 (30546726)
• Project Period (FY): 2009 – 2011
• Keywords: 食道外科学 / CD24

Research Abstract

Mortality rates due to gastric cancer are high in Japan. To improve patient prognosis, new biomarkers for diagnosis and treatment are urgently required. In this study we investigated the role of CD24, a cell adhesion glycoprotein implicated in tumor cell proliferation, which is used as a prognostic marker in various cancers.
CD24 upregulation was significantly correlated with depth of invasion and pathological high stage. We observed a relationship between high CD24 expression and lymph node metastasis, venous invasion and lymphatic invasion, however there were not statistically significant. CD24 expression tended to be higher in cell lines derived from differentiated gastric carcinoma, including those derived from lymph node metastasis.
CD24 expression is a potential biomarker for digestive cancer prognosis, and provides a new molecular target for therapeutic strategies.

Research Products

• [Journal Article] CD24 expression is associated with progression of gastric cancer (2012)
  • Author(s): Takahashi M, Nakajima M, Ogata H, Domeki Y, Ohtsuka K, Ihara1 K, Kurayama E, Yamaguchi S, Sasaki K, Miyachi K, Kato H
  • Journal Title: Hepatogastroenterology Volume: (In press)
  • DOI: DOI:10.5754/hge12763
  • Peer Reviewed
• [Journal Article] Comprehensive analysis of genes invo lved in the malignancy of gastrointestinal stromal tumors (2010)
  • Author(s): Tsumuraya M, Kato H, Miyachi K, Sasaki K, Tsubaki M, Akimoto K, Sunagawa M
  • Journal Title: Anticancer Research Volume: Vol.30 Pages: 2705-2712
  • URL: http://ar.iiarjournals.org/gca?submit=Go&gca=anticanres%3B30%2F7%2F2705&allch=
  • Peer Reviewed
• [Journal Article] CD24 Expression Is a Novel Prognostic Factor in Esophageal Squamous Cell Carcinoma (2009)
  • Author(s): Sano A, Kato H, Sakurai S, Sakai M, Tanaka N, Inose T, Saito K, Sohda M, Nakajima M, Nakajima T, Kuwano H
  • Journal Title: Ann Surg Oncol Volume: 16巻 Pages: 506-514
  • URL: http://link.springer.com/article/10.1245%2Fs10434-008-0252-0
  • Peer Reviewed
• [Presentation] 胃癌におけるCD24 発現と臨床病理学的検討 (2011)
  • Author(s): 高橋 雅一
  • Organizer: 第49回日本癌治療学会学術集会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2011-10-27
• [Presentation] 胃癌におけるCD24 発現と臨床病理学的因子・予後とその関連 (2011)
  • Author(s): 高橋 雅一
  • Organizer: 第7回日本消化管学会総会学術集会
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2011-02-18
• [Presentation] 食道癌切除症例におけるCD24 発現の検討 (2011)
  • Author(s): 佐野 彰彦
  • Organizer: 第7回日本消化管学会総会学術集会
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2011-02-18
• [Presentation] 胃癌におけるCD24 発現と臨床病理学的検討 (2010)
  • Author(s): 高橋 雅一
  • Organizer: 第21回日本消化器癌発生学会総会
  • Place of Presentation: 軽井沢プリンスホテルウエスト(軽井沢町)
  • Year and Date: 2010-11-18