2011 Fiscal Year Final Research Report

New cancer therapy targeting chemokine-network in esophageal cancer

Research Project

Project/Area Number	21591712
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Digestive surgery
Research Institution	Keio University
Principal Investigator	TAKEUCHI Hiroya 慶應義塾大学, 医学部, 講師 (20265838)
Co-Investigator(Kenkyū-buntansha)	KITAGAWA Yuko 慶應義塾大学, 医学部, 教授 (20204878) IRINO Tomoyuki 慶應義塾大学, 医学部, 助教 (20445216) NISHI Tomohiko 慶應義塾大学, 医学部, 助教 (70445386)
Project Period (FY)	2009 – 2011
Keywords	食道扁平上皮癌 / ケモカインレセプター / CCR7 / CXCR4 / CCL21 / CXCL12
Research Abstract	We investigated the CCR7 expression of 105 consecutive patients with esophageal squamous cell carcinoma(ESCC) by immunohistochemistry, showing that positive CCR7 expression was significantly correlated with lymph node metastasis and poor prognosis. Cell mobility analyzer to directly assess cell migratory movements showed that CCR7-expressing ESCC cells exhibited a significant increase in velocity in response to the CC-chemokine ligand 21/secondary lymphoid-tissue chemokine(CCL21/SLC), a specific ligand for CCR7. We also investigated the CXCL12 of 81 patients with ESCC by immunohistochemistry, showing that positive CXCL12 expression was significantly correlated with poor prognosis. ESCC cell growth which over-expressed CXCL12 was significantly suppressed by AMD3100.

(4 results)