2011 Fiscal Year Final Research Report
Regeneration of fully circular and soft walled intestine with peristalsis using amniotic membrane-in dog experiment
| Project/Area Number |
21591737
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Doshisha University |
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Principal Investigator |
HAGIWARA Akeo 同志社大学, 生命医科学部, 教授 (90198648)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 小腸大腸肛門外科学 / 再生医学 / 腸管再生 / 羊膜 |
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| Research Abstract |
Amniotic membrane is one of an useful material for regeneration of fully circular walled intestine with peristalsis. Considering its difficulty in clinical application, however, we have devised another material of thermally cross-linked gelatin membrane instead of amniotic membrane. The examinations using rats and dogs have revealed that the thermally cross-linked gelatin membrane effectively prevents adhesions and regenerates the intestinal wall including peritoneum by providing with high performing scaffolds for tissue-regeneration.
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