Cellular and molecular target therapy for hepatic ischemia-reperfusion injury

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591748
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Hiroshima University
• Principal Investigator: TASHIRO Hirotaka 広島大学, 大学院・医歯薬学総合研究科, 准教授 (90359894)
• Co-Investigator(Kenkyū-buntansha): KIMURA Yasuhiro 広島大学, 大学院・医歯薬学総合研究科, 准教授 (80314756)
• Project Period (FY): 2009 – 2011
• Keywords: 肝虚血再灌流障害 / 肝星細胞 / Rhoキナーゼ阻害剤 / リポソーム / ビタミンA

Research Abstract

We have developed the vitamine A-coupled liposomes containing Rho kinase inhibitor to attenuate the hepatic ischemia-reperfusion injury in rat. First, GFP was specifically detected in the sinusoidal linings when the vitamine A-coupled liposome containing GFP was administered systemically. We have also confirmed that the liposomes have ameliorated the ischemia-reperfusion injuries at the dose of one-hundreds compared with alone Rho kinase inhibitor, with attenuating the side effects such as a hypotension

Research Products

• [Journal Article] Rho inhibitor prevents ischemia-reperfusion injury in the rat steatotic liver (2012)
  • Author(s): Kuroda S, Tashiro H, Igarashi Y, Tanimoto Y, Nambu J, Oshita A, Kobayashi T, Amano H, Tanaka Y, Ohdan H.
  • Journal Title: J Hepatology Volume: 56 Pages: 146-152
  • Peer Reviewed
• [Journal Article] Impact of pegylated-interferon therapy on outcomes of patients with hepatitis C virus-related hepatocellularcar cinoma after curative hepatic resection (2012)
  • Author(s): Tanimoto Y, Tashiro H, Aikata H, AmanoH, Oshita A, Kobayashi T, Kuroda K, Tazawa H, Takahashi S, Itamoto T, Chayama K, Ohdan H.
  • Journal Title: Ann Surg Oncol Volume: 19 Pages: 418-425
  • Peer Reviewed
• [Journal Article] Identification of patients likely to benefit from metastasectomy in stage IV colorectal cancer (2012)
  • Author(s): Shimomura M, Okajima M, Hinoi T, Egi H, Takakura Y, Kawaguchi Y, Tokunaga M, Adachi T, Tashiro H, Ohdan H.
  • Journal Title: Int J Colorectal Dis Volume: (in press.)
  • Peer Reviewed
• [Journal Article] Safety and Feasibility of Diet-Treated Donors With Steatotic Livers at the Initial Consultation for Living-Donor Liver Transplantation (2012)
  • Author(s): Oshita A, Tashiro H, Amano H, Kobayashi T, Onoe T, Ide K, Takaki S, Takahashi S, Arihiro K, Chayama K, Ohdan H.
  • Journal Title: Transplantation Volume: (in press.)
  • Peer Reviewed
• [Journal Article] Prognostic Significance of Antithrombin III Levels for Outcomes in Patients with Hepatocellular Carcinoma After Curative Hepatectomy (2012)
  • Author(s): Iwako H, Tashiro H, Amano H, TanimotoY, Oshita A, Kobayashi T, Kuroda S, Tazawa H, Nambu J, Mikuriya Y, Abe T, Ohdan H.
  • Journal Title: Ann Surg Oncol Volume: (in press.)
  • Peer Reviewed
• [Journal Article] External Validation of two nomograms for predicting patients survival after hepatic resection for metastatic colorectal cancer (2011)
  • Author(s): Takakura Y, Okajima M, Kanemitsu Y, Kuroda S, Egi H, Hinoi T, Tashiro H, Ohdan H.
  • Journal Title: World JSurg Volume: 35 Pages: 2275-2282
  • Peer Reviewed
• [Journal Article] Significance of platelet count in the outcomes of hepatectomized patients with hepatocellular carcinoma exceeding the Mi lan criteria (2011)
  • Author(s): Amano H, Tashiro H, Oshita A, Kobayashi T, Tanimoto Y, Kuroda S, Tazawa H, Itamoto T, Asahara T, Ohdan H.
  • Journal Title: J Gastrointest Surg Volume: 15 Pages: 1173-1181
  • Peer Reviewed
• [Journal Article] Treatment strategy for early hepatocellular carcinomas : Comparison of radiofrequency ablation with or without transcatheter arterial chemoembolization and surgical resection (2011)
  • Author(s): Tashiro H, Aikata H, Waki K, Amano H, Oshita H, Kobayashi T, Tanimoto Y, Kuroda S, Tazawa H, Chayama K, AsaharaT, Ohdan H.
  • Journal Title: J Surg Oncol Volume: 104 Pages: 3-9
  • Peer Reviewed
• [Journal Article] Factors relating to tumor do not influence the prognosis of solitary hepatocellular carcinoma afterpartial hepatectomy (2011)
  • Author(s): Kobayashi T, Itamoto T, Tashiro H, Kuroda S, Tazawa H, Tanimoto Y, Ushitora Y, Oshita A, Amano H, Ohdan H.
  • Journal Title: J HBP science Volume: 18 Pages: 689-699
  • Peer Reviewed
• [Journal Article] SelectionCriteria for Hepatectomy in Patients with Hepatocellular Carcinoma Classified as Child-Pugh Class B (2011)
  • Author(s): Kuroda S, Tashiro H, Kobayashi T, Oshita A, Amano H, Ohdan H.
  • Journal Title: World J Surg Volume: 35 Pages: 834-841
  • Peer Reviewed
• [Journal Article] Splenectomy in chronic hepatic disorders : portal veinthrombosis and improvement of liver function (2011)
  • Author(s): Ushitora Y, Tashiro H, Takahashi S, Amano H, Oshita A, Kobayshi T, ChayamaK, Ohdan H.
  • Journal Title: Digestive Surgery Volume: 28 Pages: 9-14
  • Peer Reviewed
• [Presentation] ドナー由来活性化リンパ球細胞療法による生体肝移植後の敗血症予防 (2011)
  • Author(s): 田代裕尊, 茶山一彰, 大段秀樹
  • Organizer: 第15回日本肝臓学会大会
  • Place of Presentation: 福岡
  • Year and Date: 20111020-23
• [Presentation] 再肝切除における術後胆汁漏の予防 (2011)
  • Author(s): 田代裕尊, 天野尋暢, 大下彰彦, 小林剛, 尾上隆司, 井手健太郎, 大段秀樹
  • Organizer: 第66回日本消化器外科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 20110713-0715
• [Presentation] Child-PughB原発性肝細胞癌に対する肝切除・肝移植症例の検討 (2011)
  • Author(s): 黒田慎太郎, 田代裕尊, 藤國宣明, 楠部潤子, 田澤宏文, 谷本新学, 小林剛, 大下彰彦, 天野尋暢, 番匠谷将孝, 井手健太郎, 尾上隆司, 大段秀樹
  • Organizer: 第66回日本消化器外科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-07-13
• [Presentation] 脂肪肝における虚血再潅流障害の機序とその治療法 (2011)
  • Author(s): 黒田慎太郎, 田代裕尊, 五十嵐友香, 谷本新学, 大下彰彦, 小林剛, 天野尋暢, 楠部潤子, 大段秀樹
  • Organizer: 第47回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-02
• [Presentation] C型慢性肝炎関連肝細胞癌切除後のPEG-IFN療法による予後改善効果 (2011)
  • Author(s): 田代裕尊, 相方浩, 谷本新学, 天野尋暢, 大下彰彦, 小林剛, 茶山一彰, 大段秀樹
  • Organizer: 第47回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-02