2011 Fiscal Year Final Research Report
Heterotopic living-donor partial liver transplantation as a therapy for cure of hemophilia
| Project/Area Number |
21591759
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nara Medical University |
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Principal Investigator |
KO Saiho 奈良県立医科大学, 医学部, 非常勤講師 (80305713)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAJIMA Yoshiyuki 奈良県立医科大学, 医学部, 教授 (00142381)
FUJIMURA Yochihiro 奈良県立医科大学, 医学部, 教授 (80118033)
SHIBATA Masaru 奈良県立医科大学, 医学部, 助教 (50405388)
MATSUMOTO Masanori 奈良県立医科大学, 医学部, 准教授 (60316081)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 異所性肝移植 / 血友病 / ADAMTS13 / 部分肝移植 / 門脈血 / 肝細胞移植 |
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| Research Abstract |
A model of heterotopic partial liver transplantation was established for curative treatment for hemophilia which was caused by deficiency of factor VIII produced in the liver. Experiment of hepatocyte transplantation using ADAMTS13 knockout mice revealed that untreated hepatocytes transplanted from wild type donor to the recipient did not produce detectable amount of ADAMTS13 activity. Clinical observations in patients with liver surgery showed that major hepatectomy resulted in significant decrease of plasma ADAMTS13 activity.
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