2011 Fiscal Year Final Research Report
Elucidation of the mechanism of perioperative kidney injury and establishment of the new strategy of kidney protection in Cardiovascular surgery.
| Project/Area Number |
21591787
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAMOTO Shunsuke 東北大学, 大学院・医学系研究科, 准教授 (20400244)
TAKAHASHI Goro 東北大学, 大学院・医学系研究科, 助教 (50526449)
ABE Takaaki 東北大学, 大学院・医学系研究科, 教授 (80292209)
SAIKI Yoshikatsu 東北大学, 大学院・医学系研究科, 教授 (50372298)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 心臓大血管外科 / 腎障害 / 腎保護 |
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| Research Abstract |
We have established the porcine renal ischemia-reperfusion injury model clamping bilateral renal arteries. Then, we assessed the degrees of kidney damage and expression of PPAR-γ and LXR-α (PPAR-γ's target gene)in the kidney comparing the PPAR-γ agonists administration group with control group. Both PPAR-γ and LXR-α are expressed in juxtaglomerular vascular endothelial cells and proximal tubule epithelial cells in both groups. Serum creatinine are increased until 4 hours after reperfusion. Pathological damage was peaked at about 2 hours after reperfusion and recovered after that. Now, we are proceeding the quantitative assessment in both groups.
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