2011 Fiscal Year Final Research Report

Direct delivery of nitric oxide synthase isozyme improves heart failure in rats` myocardial infarction model.

Research Project

Project/Area Number	21591802
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Thoracic surgery
Research Institution	Wakayama Medical University
Principal Investigator	HONDA Kentaro 和歌山県立医科大学, 医学部, 助教 (60508018)
Co-Investigator(Kenkyū-buntansha)	OKAMURA Yoshitaka 和歌山県立医科大学, 医学部, 教授 (80245076) MAEDA Masanobuz 和歌山県立医科大学, 医学部, 教授 (80181593) KOHSAKA Akira 和歌山県立医科大学, 医学部, 講師 (00458051) NISHIMURA Yoshiharu 和歌山県立医科大学, 医学部, 講師 (70254539) UCHITA Shunji 和歌山県立医科大学, 医学部, 講師 (10246556)
Project Period (FY)	2009 – 2011
Keywords	急性心筋梗塞 / 一酸化窒素合成酵素 / 心不全 / タンパク質導入 / タンパク質治療
Research Abstract	It was successful that direct delivery of nitric oxide synthase(NOS) isozymes into myocardium in acute myocardial infarction rat model. The direct delivery of NOS reduced the size of infarcted area in acute phase after acute myocardial infarction. And then the direct delivery NOS of improved cardiac function.

(1 results)