Direct delivery of nitric oxide synthase isozyme improves heart failure in rats` myocardial infarction model.

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591802
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Wakayama Medical University
• Principal Investigator: HONDA Kentaro 和歌山県立医科大学, 医学部, 助教 (60508018)
• Co-Investigator(Kenkyū-buntansha): OKAMURA Yoshitaka 和歌山県立医科大学, 医学部, 教授 (80245076) ; MAEDA Masanobuz 和歌山県立医科大学, 医学部, 教授 (80181593) ; KOHSAKA Akira 和歌山県立医科大学, 医学部, 講師 (00458051) ; NISHIMURA Yoshiharu 和歌山県立医科大学, 医学部, 講師 (70254539) ; UCHITA Shunji 和歌山県立医科大学, 医学部, 講師 (10246556)
• Project Period (FY): 2009 – 2011
• Keywords: 急性心筋梗塞 / 一酸化窒素合成酵素 / 心不全 / タンパク質導入 / タンパク質治療

Research Abstract

It was successful that direct delivery of nitric oxide synthase(NOS) isozymes into myocardium in acute myocardial infarction rat model. The direct delivery of NOS reduced the size of infarcted area in acute phase after acute myocardial infarction. And then the direct delivery NOS of improved cardiac function.

Research Products

• [Presentation] Direct transduction of vascular endothelial growth factor into cardiomyocytes reduced infarcted areas in acute myocardial infarction rats (2010)
  • Author(s): Masahiro Kaneko, Atsutoshi Hatada, Yoshiharu Nishimura, Shunji Uchita, Koji Toguchi, Kentaro Honda, Takeo Nakai, Hidefumi Waki, Akira Kohsaka, Yoshitaka Okamura, Masanobu Maeda
  • Organizer: 第87回日本生理学会
  • Place of Presentation: 盛岡
  • Year and Date: 20100519-21