2011 Fiscal Year Final Research Report
Clinical study on adoptive immunotherapy with autologous gammadelta T-lymphocyte for patients with pulmonary metastasis from colorectal cancer.
| Project/Area Number |
21591809
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NAKAJIMA Jun 東京大学, 医学部附属病院, 教授 (90188954)
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| Co-Investigator(Kenkyū-buntansha) |
KAKIMI Kazuhiro 東京大学, 医学部附属病院, 特任准教授 (80273358)
MURKAWA Tomohiro 東京大学, 医学部附属病院, 講師 (50359626)
FUKAMI Takeshi 東京大学, 医学部附属病院, 助教 (40396742)
YOSHIDA Yukihiro 東京大学, 医学部附属病院, 特任助教 (00529050)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 転移性肺腫瘍 / 結腸直腸癌 / 術後合併療法 / 免疫療法 / 自己活性化リンパ球療法 / γδT細胞 |
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| Research Abstract |
Patients with pulmonary metastasis from colorectal cancer, which is an advanced form of the disease, can be cured by surgical resection. However, they are much likely to suffer from the recurrence. We performed a clinical trial of adoptive immunotherapy on the patients after curative resection of pulmonary metastasis from colorectal cancer ; gamma-delta fraction of T-lymphocytes was retrieved from the patients, incubated/activated in vitro, and then returned to the same patients. This treatment was able to carried out safely. Compared with the historical control group, there was no significant difference in survival rate or recurrence-free survival.
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