2011 Fiscal Year Final Research Report
Combined therapy of VEGF plasmid injection and MSC transplantation for Moyamoya disease
| Project/Area Number |
21591840
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Okayama University |
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Principal Investigator |
TOKUNAGA Koji 岡山大学, 岡山大学病院, 講師 (40294467)
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| Co-Investigator(Kenkyū-buntansha) |
HISHIKAWA Tomohito 岡山大学, 岡山大学病院, 助教 (60509610)
KAMEDA Masahiro 岡山大学, 岡山大学病院, 医員 (50586427)
YASUHARA Takao 岡山大学, 岡山大学病院, 助教 (50457214)
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| Co-Investigator(Renkei-kenkyūsha) |
DATE Isao 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70236785)
SUGIU Kenji 岡山大学, 岡山大学病院, 講師 (40325105)
KUROZUMI Kazuhiko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (20509608)
AGARI Takashi 岡山大学, 岡山大学病院, 助教 (60423290)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 実験脳外科学 / 電気刺激療法 |
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| Research Abstract |
We confirmed that revascularization and MSC transplantation have therapeutic efficacy in behavioral recovery of Moyamoya model of rats. Because VEGF plasmid injection combined with revascularization did not show better behavioral recovery compared with revascularization only, we looked for more suitable angiogenic factor for combined therapy of angiogenic factor and MSC transplantation, and confirmed apelin-APJ system was activated in chronic cerebral hypoperfusion. Moreover, we developed less invasive monkey ischemia model using an endovascular technique.
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