2011 Fiscal Year Final Research Report
Protective effect of rare sugar D-allose on ischemic injuries occurred by brain embolism.
| Project/Area Number |
21591846
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Fuminori 香川大学, 医学部, 准教授 (40271085)
ITANO Toshifumi 香川大学, 大学本部, 理事 (60145042)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 希少糖 / D-アロース / 脳梗塞 / 血液脳関門 / 虚血再還流障害 / 活性酸素 |
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| Research Abstract |
We performed the experiment using a rat model with brain ischemia and reperfusion. Male SD rats weighing 350-400g were used. The ischemic model was made by placing a nylon thread in the mid brain artery for 60 min. D-allose reduces the impaired region of brain embolism in a dose dependent manner. D-allose(50mg/ kg～800mg/ kg) was administered intravenously. Oxidative stress markers were markedly reduced by D-allose. Thus, D-allose was revealed to reduce the impaired region of brain embolism in a dose-dependent manner.
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Research Products
(6 results)
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[Journal Article] Anti-oxidative effects of D-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat2011
Author(s)
Nakamura T, Tanaka S, Hirooka K, Toyoshima T, Kawai N, Tamiya T, Shiraga F, Tokuda M, Keep RF, Itano T, Miyamoto O
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Journal Title
Neurosci Lett
Volume: 487(1)
Pages: 103-6
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