2011 Fiscal Year Final Research Report
Effect of statins on the blood-brain barrier
| Project/Area Number |
21591848
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | 独立行政法人国立病院機構長崎医療センター (2011)
Department of Clinical Research, National Hospital Organization Nagasaki Medical Center (2009-2010) |
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Principal Investigator |
MOROFUJI Yoichi 独立行政法人国立病院機構長崎医療センター, 臨床研究センター, 客員研究員 (40437869)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Kentaro 長崎大学, 医学部歯学部付属病院, 助教 (40404222)
SO Gohei 長崎大学, 医学部歯学部付属病院, 医員 (80530427)
TAKAHATA Hideaki 独立行政法人国立病院機構, 長崎医療センター・脳神経外科, 医師 (80607854)
TAKESHITA Tomonori 長崎大学, 医学部歯学部付属病院, 医員 (30597365)
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| Project Period (FY) |
2009 – 2011
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| Keywords | スタチン / 血液脳関門 / タイトジャンクション / 脳卒中 |
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| Research Abstract |
We investigated the effect of pitavastatin on barrier functions of an in vitro BBB model with primary cultures of rat brain capillary endothelial cells(RBEC). Our data indicate that pitavastatin strengthens the barrier integrity in primary cultures of RBEC. The BBB-stabilizing effect of pitavastatin may be mediated partly through inhibition of the mevalonate pathway and subsequent up-regulation of claudin-5 expression.
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