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2011 Fiscal Year Final Research Report

Development of functional brain treatment system by integrating white matter tractographies of the brain

Research Project

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Project/Area Number 21591881
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionKyorin University

Principal Investigator

MARUYAMA Keisuke  杏林大学, 医学部, 助教 (10345192)

Co-Investigator(Renkei-kenkyūsha) KURITA Hiroki  埼玉医科大学, 医学部, 教授 (70262003)
KAMADA Kyousuke  旭川医科大学, 医学部, 教授 (80372374)
KOGA Tomoyuki  埼玉医科大学, 医学部, 助教 (40456124)
Project Period (FY) 2009 – 2011
KeywordsMRI / 拡散テンソル / 定位放射線治療 / 手術支援
Research Abstract

After imaging processing of diffusion tensor tractography derived from the brain MRI, tractography was integrated to treatment planning software for stereotactic radiosurgery of the brain as well as neuronavigation system for microsurgery. As a result, we found that stereotactic irradiation of 10Gy to the temporal fibers of the arcuate fasciculus caused language disturbance, while that to the frontal fibers did not. If the dose to the pyramidal tract was set within 20 Gy, the optic radiation and the temporal fibers of the arcuate fasciculus within 8 Gy, and the frontal fibers of the arcuate fasciculus within 20 Gy during stereotactic radiosurgery, the rate of complication could extremely be reduced. By its integration to neuronavigation, we found linear relationship between the intensity of electrical stimulation and the distance to the pyramidal tract.

  • Research Products

    (47 results)

All 2012 2011 2010 2009 Other

All Journal Article (20 results) (of which Peer Reviewed: 14 results) Presentation (20 results) Book (7 results)

  • [Journal Article] Outcomes of diffusion-tensor tractography-integrated stereotactic radiosurgery2012

    • Author(s)
      Koga T, Maruyama K, Kamada K, Ota T, Shin M, Itoh D, Kunii N, Ino K, Terahara A, Aoki S, Masutani Y, Saito N
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 82 Pages: 799-802

    • Peer Reviewed
  • [Journal Article] Contribution of technological progress, inter-operator differrence and experience of operators in Gamma Knife radiosurgery for arteriovenous malformation2011

    • Author(s)
      Koga T, Shin M, Maruyama K, Kurita H, Kawamoto S, Saito N
    • Journal Title

      Acta Neurochir(Wien)

      Volume: 153 Pages: 879-872

    • Peer Reviewed
  • [Journal Article] 全脳放射線療法後の肺小細胞癌脳転移再発病変に対する定位放射線治療2011

    • Author(s)
      永山和樹、丸山啓介、中村正直、戸成綾子、楠田順子、高山誠、塩川芳昭
    • Journal Title

      定位放射線治療

      Volume: 15 Pages: 113-119

    • Peer Reviewed
  • [Journal Article] Highdefinition fiber tractography and language(Response)2010

    • Author(s)
      Maruyama K, Kamada K, Koga T
    • Journal Title

      J Neurosurg

      Volume: 113 Pages: 156-158

  • [Journal Article] Long-term outcomes of stereotactic radiosurgery for arteriovenous malformations in the thalamus2010

    • Author(s)
      Koga T, Shin M, Maruyama K, Terahara A, Saito N
    • Journal Title

      Neurosugery

      Volume: 67 Pages: 398-403

    • Peer Reviewed
  • [Journal Article] 頭蓋底病変に対する経鼻的到達法2010

    • Author(s)
      丸山啓介
    • Journal Title

      Current Insights in Neurological Science

      Volume: 18 Pages: 7

  • [Journal Article] 下垂体腫瘍経鼻的腫瘍摘出術(顕微鏡/内視鏡)2010

    • Author(s)
      丸山啓介
    • Journal Title

      Brain Nursing

      Volume: 26 Pages: 44-46

  • [Journal Article] 脳内出血に対する外科治療の現状と課題2010

    • Author(s)
      岡村耕一、山口竜一、脊山英徳、丸山啓介、栗田浩樹、岡野晴子、小林洋和、西山和利、高橋秀寿、塩川芳昭
    • Journal Title

      脳卒中

      Volume: 32 Pages: 589-594

    • Peer Reviewed
  • [Journal Article] Arcuate fasciculus tractography integrated into gamma knife surgery2009

    • Author(s)
      Maruyama K, Koga T, Kamada K, Ota T, Itoh D, Ino K, Igaki H, Aoki S, Masutani Y, Shin M, Saito N
    • Journal Title

      J Neurosurg

      Volume: 111 Pages: 520-526

    • Peer Reviewed
  • [Journal Article] The value of image coregistration during stereotactic radiosurgery2009

    • Author(s)
      Koga T, Maruyama K, Igaki H, Tago M, Saito N
    • Journal Title

      Acta Neurochir(Wien)

      Volume: 151 Pages: 465-471

    • Peer Reviewed
  • [Journal Article] Assessment of arteriovenous malformations by time-resolved contrast-enhanced 3D MR angiography at 3.0tesla2009

    • Author(s)
      Kunishima K, Mori H, Itoh D, Aoki S, Kabasawa H, Koga T, Maruyama K, Masumoto T, Abe O, Ohtomo K
    • Journal Title

      J Neurosurg

      Volume: 110 Pages: 492-499

    • Peer Reviewed
  • [Journal Article] Long-term control of disseminated pleomorphic xanthoastrocytoma with anaplastic features by means of stereotactic irradiation2009

    • Author(s)
      Koga T, Morita A, Maruyama K, Tanaka M, Ino Y, Shibahara J, Louis DN, Reifenberger G, Itami J, Hara R, Saito N, Todo T
    • Journal Title

      Neurooncology

      Volume: 11 Pages: 446-451

    • Peer Reviewed
  • [Journal Article] Gamma Knife surgery for skull base meningioma2009

    • Author(s)
      Igaki H, Maruyama K, Koga T, Murakami N, Tago M, Shin M, Nakagawa K, Ohtomo K
    • Journal Title

      Neurol Med Chir(Tokyo)

      Volume: 49 Pages: 456-461

    • Peer Reviewed
  • [Journal Article] 脳動静脈奇形2009

    • Author(s)
      丸山啓介
    • Journal Title

      Current Insights in Neurological Science

      Volume: 17(1) Pages: 6

  • [Journal Article] 脳動静脈奇形に対する定位放射線治療2009

    • Author(s)
      丸山啓介
    • Journal Title

      脳神経外科速報

      Volume: 19 Pages: 1152-1158

  • [Journal Article] 脳内出血2009

    • Author(s)
      丸山啓介
    • Journal Title

      Current Insights in Neurological Science

      Volume: 17(3) Pages: 6

  • [Journal Article] One-stage clipping of bilateral middle cerebral aneurysms via pterional keyhole approach

    • Author(s)
      Maruyama K, Kurita H, Yamaguchi R, Noguchi A, Shiokawa Y
    • Journal Title

      Neurol Med Chir(Tokyo)

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Serum pentosidine, an advanced glycation end product, indicates poor outcomes after acute ischemic stroke

    • Author(s)
      Ikeda T, Maruyama K, Ito N, Utagawa A, Nagane M, Shiokawa Y
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Extended field stereotactic radiosurgery for recurrent glioblastoma

    • Author(s)
      Koga T, Maruyama K, Tanaka M, Ino Y, Saito N, Nakagawa K, Shibahara J, Todo T
    • Journal Title

      Cancer

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Integration of corticospinal tractography reduces motor complications after radiosurgery

    • Author(s)
      Koga T, Shin M, Maruyama K, Kamada K, Ota T, Itoh D, Kunii N, Ino K, Aoki S, Masutani Y, Igaki H, Onoe T, Saito N
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: (in press)

    • Peer Reviewed
  • [Presentation] 脳腫瘍の術中navigationで参照する適切な融合画像の選択2012

    • Author(s)
      丸山啓介, 他
    • Organizer
      第35回日本脳神経CI学会
    • Place of Presentation
      横浜
    • Year and Date
      2012-03-03
  • [Presentation] 再発悪性神経膠腫に対する定位的放射線療法の治療効果2011

    • Author(s)
      小林啓一、丸山啓介, 他
    • Organizer
      第29回日本脳腫瘍学会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-11-28
  • [Presentation] 経蝶形骨アプローチにおける内視鏡の必要度:拡大法と従来法の比較検討2011

    • Author(s)
      丸山啓介, 他
    • Organizer
      第18回日本神経内視鏡学会
    • Place of Presentation
      岡山
    • Year and Date
      2011-11-17
  • [Presentation] 基本的開頭法と整容への配慮2011

    • Author(s)
      丸山啓介, 他
    • Organizer
      第7回脳神経外科手術夜話
    • Place of Presentation
      三鷹
    • Year and Date
      2011-11-11
  • [Presentation] 術中ナビゲーションにおけるT2反転および錐体路・PET画像融合の有用性2011

    • Author(s)
      小林啓一、丸山啓介, 他
    • Organizer
      第70回日本脳神経外科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-10-12
  • [Presentation] 脳動脈瘤処置に必要なクリッピング以外の手術手技2011

    • Author(s)
      丸山啓介, 他
    • Organizer
      第70回日本脳神経外科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-10-12
  • [Presentation] 特異な所見を呈する破裂脳動脈瘤への手術手技のバリエーション2011

    • Author(s)
      丸山啓介, 他
    • Organizer
      第40回日本脳卒中の外科学会
    • Place of Presentation
      京都
    • Year and Date
      2011-07-31
  • [Presentation] 脳神経外科手術におけるフィブリン糊の役割2011

    • Author(s)
      丸山啓介
    • Organizer
      CSLベーリング社内レクチャー
    • Place of Presentation
      東京
    • Year and Date
      2011-07-05
  • [Presentation] 傍鞍部病変に対する拡大経蝶形骨アプローチ2011

    • Author(s)
      丸山啓介, 他
    • Organizer
      第23回日本頭蓋底外科学会
    • Place of Presentation
      大阪
    • Year and Date
      2011-06-17
  • [Presentation] Integration of diffusion tensor tractography into radiosurgery-systematic review of our experience2011

    • Author(s)
      Maruyama K, Koga T, Kamada K, et al
    • Organizer
      10th Congress of the International Stereotactic Radiosurgery Society
    • Place of Presentation
      Paris
    • Year and Date
      2011-05-09
  • [Presentation] 脳神経外科学生教育へのiPadの導入2011

    • Author(s)
      丸山啓介, 他
    • Organizer
      第20回脳神経外科手術と機器学会
    • Place of Presentation
      徳島
    • Year and Date
      2011-04-08
  • [Presentation] 拡散テンソルtractographyの脳神経外科治療への適用2011

    • Author(s)
      丸山啓介、甲賀智之, 他
    • Organizer
      第34回日本脳神経CI学会
    • Place of Presentation
      米子
    • Year and Date
      2011-02-04
  • [Presentation] 拡大経蝶形骨到達法を導入後の鞍結節部髄膜腫に対する術式選択2010

    • Author(s)
      丸山啓介, 他
    • Organizer
      第69回日本脳神経外科学会総会
    • Place of Presentation
      博多
    • Year and Date
      2010-10-29
  • [Presentation] 拡大経蝶形骨到達法を導入後の鞍結節部髄膜腫に対する術式選択2010

    • Author(s)
      丸山啓介, 他
    • Organizer
      第15回日本脳腫瘍の外科学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-10-01
  • [Presentation] 拡大経蝶形骨到達法を導入後の鞍結節部髄膜腫に対する術式選択2010

    • Author(s)
      丸山啓介, 他
    • Organizer
      第22回日本頭蓋底外科学会
    • Place of Presentation
      久留米
    • Year and Date
      2010-07-15
  • [Presentation] Key hole approachによる両側未破裂脳動脈瘤の一期的クリッピング2010

    • Author(s)
      丸山啓介、栗田浩樹, 他
    • Organizer
      第39回日本脳卒中の外科学会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-04-17
  • [Presentation] 経鼻経蝶形骨手術における内視鏡の役割と弱点2009

    • Author(s)
      丸山啓介, 他
    • Organizer
      第16回日本神経内視鏡学会
    • Place of Presentation
      富山
    • Year and Date
      2009-12-05
  • [Presentation] Distal transsylvian key hole approach for supratentorial aneurysms2009

    • Author(s)
      Maruyama K, Kurita H, et. al
    • Organizer
      9th Internatonal Conference on Cerebrovascular Surgery
    • Place of Presentation
      名古屋
    • Year and Date
      2009-11-13
  • [Presentation] 経鼻経蝶形骨手術における内視鏡の役割と弱点2009

    • Author(s)
      丸山啓介, 他
    • Organizer
      第68回日本脳神経外科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-15
  • [Presentation] Integrating tractography to prevent morbidity of radiosurgery2009

    • Author(s)
      Maruyama K, Koga T, Kamada K, et. al
    • Organizer
      9th Congress of the International Stereotactic Radiosurgery Society
    • Place of Presentation
      Seoul
    • Year and Date
      2009-06-10
  • [Book] 下垂体腫瘍-マイクロ、内視鏡、SRSの選択. in塩川芳昭(編): NS now No.15傍鞍部病変の手術2011

    • Author(s)
      丸山啓介, 他
    • Total Pages
      181-190
    • Publisher
      メジカルビュー社
  • [Book] 脳の腫れ:術中および術後の対応. in大畑建治(編): NS now No.18脳神経外科手術のトラブルシューティング2010

    • Author(s)
      丸山啓介, 他
    • Total Pages
      42-51
    • Publisher
      メジカルビュー社
  • [Book] 側頭葉・後頭葉病変の定位放射線治療とtractography. in斉藤延人(編):ビジュアル脳神経外科2側頭葉・後頭葉2010

    • Author(s)
      丸山啓介、甲賀智之
    • Total Pages
      200-207
    • Publisher
      メジカルビュー社
  • [Book] Aesculap MIETHKE proGAVシャントシステム手技考察2010

    • Author(s)
      丸山啓介
    • Total Pages
      6
    • Publisher
      ビー・ブラウンエースクラップ株式会社
  • [Book] 脳動静脈奇形・海綿状血管奇形. in寺本明(編): NS now No.9無症候性脳外科疾患の治療戦略2010

    • Author(s)
      丸山啓介、栗田浩樹
    • Total Pages
      87-95
    • Publisher
      メジカルビュー社
  • [Book] 定位放射線治療の適応と治療成績. in田村晃,松谷雅生,清水輝夫(編): EBMに基づく脳神経疾患の基本治療指針改訂第3版2010

    • Author(s)
      丸山啓介
    • Total Pages
      637-640
    • Publisher
      メジカルビュー社
  • [Book] Radiosurgery for brainstem AVM. in Niranjan A, Lunsford LD(eds): Gamma knife radiosurgery for brain vascular malformations, Progress in Neurological Surgery

    • Author(s)
      Maruyama K, Koga T, Niranjan A, Kondziolka D, Flickinger JC, Lunsford LD
    • Publisher
      Karger(in press)

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Published: 2013-07-31  

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