2011 Fiscal Year Final Research Report
Development of chelate-setting cements for bone grafting
| Project/Area Number |
21591905
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
AIZAWA Mamoru 明治大学, 理工学部, 教授 (10255713)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 移植・再生医療 / 再生医学 / 臨床 / 骨移植 |
|---|
| Research Abstract |
We have successfully developed novel "chelate-setting apatite cement" using hydroxyapatite particles surface-modified with inositol phosphate. As we have examined the biocompatibility of this apatite cement, it showed good cell differentiation, attachment and proliferation, and bone induction both In vitro and In vivo. Thus, this present study demonstrates that this apatite cement can be useful as a new bone substitute for bone grafting in the spine.
|
-
[Journal Article] Establishment of a Real-Time, Quantitative, and Reproducible Mouse Model of Staphylococcus Osteomyelitis Using Bioluminescence Imaging2012
Author(s)
H. Funao, K. Ishii, S. Nagai, A. Sasaki, T. Hoshikawa, M. Aizawa, Y. Okada, K. Chiba, S. Koyasu, Y. Toyama and M. Matsumoto
-
Journal Title
Infection and Immunity
Volume: 80
Pages: 733-741
Peer Reviewed
-
-
-
-
-
-
