2011 Fiscal Year Final Research Report
Regenerative repair of bone defeots with osteoinduotive hydroxyapatite fabr icated to match the defect and implanted with combined use of computer-aided design, computer-aided manufaoturing, and computer-assisted surgery systems : a feasibility study in a canine model
| Project/Area Number |
21591922
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Osaka City University |
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Principal Investigator |
IWAKI Hiroyoshi 大阪市立大学, 大学院・医学研究科, 准教授 (20381981)
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| Co-Investigator(Kenkyū-buntansha) |
MINODA MINODA Yukihide 大阪市立大学, 大学院・医学研究科, 講師 (90453133)
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| Co-Investigator(Renkei-kenkyūsha) |
YANO Koichi 大阪労災病院, 整形外科
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| Project Period (FY) |
2009 – 2011
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| Keywords | 骨形成蛋白(Bone morphogenetic protoin, BMP) / 巨大骨欠損 / 解剖学的再建 / Computer aided design / Computer Rided manufacturing / Computer navigation system / ヒーグル犬 |
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| Research Abstract |
Currently, regenerative repair of large bone detect is a challenging issue. The aim of this study was to achieve repair of large bone defects to the original three-dimensional(3D) anatomical state. An imaginary spherical malignant bone tumor of was placed in the left ilium of a canine on the 3D imaue. Resection of the whole tumor was planned preoperatively by using computer-aided design software. An image of the implant to fill the resulting bone defect was constructed on the computer image. A porous hydroxyapatite implant identical to the imaged bone defect was made with a computer-aided manufacturing system. To resect the iliac bone as planned preoperatively on the 3^CT image, computer-aided surgery was performed. The defect was filled with the fabricated implant and coated with a putty carrier with BMP-2.New bone formation was noted around each implant on CT images and remodeled to restore the original anatomy of the ilium on serial CT images. This new method may enable efficacious and precise regenerative repair of large bone defect without bone grafting.
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Research Products
(32 results)
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[Presentation] Intra-Operative Assessment Of Mid-Flexion Instability In Total Knee Arthropalsty2012
Author(s)
Minoda Y, Nakagawa S, Kadoya Y, Kobayashi A, Tomari H, Kondo M, Iwaki H, Ikebuchi M, Yoshida T, Matsui Y, Sumitomo A, Sugama R, Mizokawa S, Higuma Y, Noguchi T, Hirakawa H, Nakamura H.
Organizer
Annual meeting of Orthopaedic Reserch Society(ORS)
Place of Presentation
San Francisco, CA, USA
Year and Date
2012-02-04
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[Presentation] The Extension Gap Becomes Tight and Valgus After Implantation of Mobile-bearing Total Knee Prosthesis2012
Author(s)
Minoda Y, Nakagawa S, Kadoya Y, Kobayashi A, Tomari H, Kondo M, Iwaki H, Ikebuchi M, Yoshida T, Matsui Y, Sumitomo A, Sugarna R, Mizokawa S, Higuma Y, Noguchi T, Hirakawa H, Nakamura H
Organizer
Annual meeting of Orthopaedic Reserch Society(ORS)
Place of Presentation
San Francisco, CA, USA
Year and Date
2012-02-04
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[Presentation] OAnnual meeting of Orthopaedic Reserch Society(ORS) perative Technique Affected The Intra-operative Joint Kinematics Of Total Knee Arhtroplasty2012
Author(s)
Minoda Y, Nakagawa S, Kadoya Y, Kobayashi A, Tomari H, Kondo M, Iwaki H, Ikebuchi M, Yoshida T, Matsui Y, Sumitomo A, Sugama R, Mizokawa S, Higuma Y, Noguchi T, Hirakawa H, Nakamura H
Organizer
Annual meeting of Orthopaedic Reserch Society(ORS)
Place of Presentation
San Francisco, CA. USA.
Year and Date
2012-02-04
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[Presentation] In Viva Wear Particles of Annealed Highly Cross-Linked Polyethylene in Total Hip Arthropalsty2012
Author(s)
Minoda, Y, Hata K, Iwaki H, Ikebuchi M, Yoshida T, Miyazaki N, Miyake Y, Nakamura H
Organizer
Annual meeting of Orthopaedic Reserch Society(ORS)
Place of Presentation
San Francisco, CA, USA
Year and Date
2012-02-04
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[Presentation] Invited Iecture ; Future expectation of TKA2011
Author(s)
Minoda Y, Kadova Y, Kobayashi A, Iwaki H, Iwakiri K, Iida T, Matusi Y, Ikebuchi M, Yoshida T, Nakamura H
Organizer
24^<th> Annual meeting of the International Society for Technology in Arthroplasty
Place of Presentation
Brues, Belgium
Year and Date
2011-09-20
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[Presentation] High incidence of anterior femoral cortex notching using navigation system in TKA2011
Author(s)
Minoda Y, Watanabe K, Iwaki H, Ikebuchi M, Yoshida T, Iida T, Ikawa T, Hashimoto Y, Nakamura H
Organizer
Annual meeting of American Association of Orthopaedic Surgeons
Place of Presentation
San Diego, CA, USA
Year and Date
2011-02-15
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[Presentation]2011
Author(s)
M inoda Y, Watanabe K, Iwaki H, Ikebuchi M, Yoshida T, Iida T, Ikawa T, Hashimoto Y, Nakamura H
Organizer
Annual meeting of American Academy of Orthopaedic Surgeons(AAOS)
Place of Presentation
San Diego, CA, USA
Year and Date
2011-02-07
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[Presentation] Comparison of BMD around the Knee between Trabecular Metal and Cemented Tibial Component ; Four-year Follow-Up Study2011
Author(s)
Minoda Y, Kobayashi A, Ikebuchi M, Iwaki H, Inori F, Hashimoto Y, Yoshida T, Iida T, Ikawa T, Yamasaki S, Nakamura H
Organizer
Annual Meeting of Orthopaedic Research Society
Place of Presentation
Long Beach, CA, USA
Year and Date
2011-01-13
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