2011 Fiscal Year Final Research Report
Analysis on mechanisms of Toll-like receptors in infected totally hip joint replacements
| Project/Area Number |
21591929
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SASAKI Kan 山形大学, 医学部, 講師 (00444034)
ASANO Tamon 山形大学, 医学部, 助教 (10344805)
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| Co-Investigator(Renkei-kenkyūsha) |
GOTO Kaoru 山形大学, 医学部, 教授 (30234975)
YAMAKAWA Mitsunori 山形大学, 医学部, 教授 (20183676)
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| Project Period (FY) |
2009 – 2011
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| Keywords | Toll様受容体 / シグナル伝達 / 人工関節 / 感染症 / 自然免疫 |
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| Research Abstract |
We have demonstrated that TLR2, 4, 5 and 9 expressions on neutrophils and macrophages in the tissue from infected totally replaced hip joints. Expression of mRNA and protein level of TLR4 on phagocytes stimulating by LPS-coating titanium particles were downregulated, but that of TLR2 were upregulated.
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