2011 Fiscal Year Final Research Report
Crosstalk of TGF signal and TRAF signal in osteoclastogenesis
| Project/Area Number |
21591932
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KADONO Yuho 東京大学, 医学部附属病院, 講師 (70401065)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Sakae 東京大学, 医学部附属病院, 教授 (50282661)
YASUI Tetsuro 東京大学, 医学部附属病院, 特任助教 (30583108)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 骨・軟骨代謝学 / 破骨細胞 |
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| Research Abstract |
We identified that TGF-beta is indispensable in osteoclastogenesis both in vitro and in vivo. We identified that Smad pathways, not non-Smad pathways, mediates the role of TGF-beta on osteoclastogenesis. We obtained the data indicating that Smad3 involves in TRAF6-TAB-TAK complex formation which exists in downstream of osteoclastogenic RANKL/RANK pathway.
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[Journal Article] Regulation of RANKL-induced osteoclastogenesis by TGF-βthrough molecular interaction between Smad3 and Traf62011
Author(s)
Tetsuro Yasui, Yuho Kadono, Masaki Nakamura, Yasushi Oshima, Takumi Matsumoto, Hironari Masuda1, Jun Hirose1, Yasunori Omata, Hisataka Yasuda, Takeshi Imamura, Kozo Nakamura, and Sakae Tanaka.
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Journal Title
J Bone Miner Res
Volume: 26(7)
Pages: 1447-56
Peer Reviewed
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