2011 Fiscal Year Final Research Report

Elucidation of the roles of SDF-1/CXCR4 signaling on degenerative changes of articular cartilage

Research Project

Project/Area Number	21591942
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Orthopaedic surgery
Research Institution	Kyoto University
Principal Investigator	ITO Hiromu 京都大学, 医学研究科, 准教授 (70397537)
Co-Investigator(Renkei-kenkyūsha)	TASHIRO Kei 京都府立医科大学, 医学研究科, 教授 (10263097) NAGASAWA Takashi 京都大学, 再生医科学研究所, 教授 (80281690) NAKAMURA Takashi 独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 研究員 (10201675)
Project Period (FY)	2009 – 2011
Keywords	変形性関節症 / 関節軟骨 / ケモカイン / SDF-1 / CXCR4
Research Abstract	We examined the roles of SDF-1/CXCR4 signaling on degenerative changes of articular cartilages. SDF-1 upregulated type II and type X collagen expression in mouse chondrocytes, but did not directly regulate mRNA expression of type X collagen. In mouse knee joint with osteoarthritic changes, SDF-1 and CXCR4 expression were upregulated. However, there were no significant osteoarthritis changes between wild-type and SDF-1+/. mice.