2011 Fiscal Year Final Research Report
Involvement of VIP Signaling in Right Cardiac Hypertrophy
| Project/Area Number |
21591981
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIZUNO Yusuke 横浜市立大学, 医学部, 講師 (80433192)
KAWAKAMI Hiromasa 横浜市立大学, 医学部, 助教 (90407958)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 右心肥大 / PACAP/VIP / 心臓神経叢 / 遺伝子治療 / レンチウイルス |
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| Research Abstract |
Elevated PACAP but not VIP signaling was associated with right ventricular hypertrophy and heart failure induced with monocrotaline in rats. PACAP-preferring receptor PCAl and the common receptor VPAC2 were up-regulated in both ventricles. Thus, PACAP signaling may play a more predominant role during cardiac hypertrophy and hear failure.
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