2013 Fiscal Year Final Research Report
Effects of Neurosteroids on Postoperative Pain
| Project/Area Number |
21591997
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | University of Tsukuba |
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Principal Investigator |
FUKUDA TAEKO 筑波大学, 医学医療系, 講師 (40228911)
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| Co-Investigator(Kenkyū-buntansha) |
HISANO Setsuji 筑波大学, 医学医療系, 教授 (70136216)
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| Project Period (FY) |
2009-04-01 – 2014-03-31
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| Keywords | ニューロステロイド / 術後痛 |
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| Research Abstract |
Effects of allopregnanolone, which is a neurosteroid, were investigated in Brennan's postsurgical rat pain model. Mechanical allodynia persisted for 7 days after surgery in finasteride, a inhibitor of allopregnanolone synthase, group. Alopregnanolone low dose (0.16 mg/kg ip) group, not high dose (1.6 mg/kg ip) group, showed higher mechanical pain threshold than that of control group after surgery. The results suggest that allopregnanolone inhibits development of hypersensitivity after surgery on multiple mechanisms, because it was not dose-dependent. Furthermore, allopregnanolone increased anti-allodynic effects of gabapentine, not indomethacin and acetoaminophen.
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