2011 Fiscal Year Final Research Report
the role of intercellular factor in the brain during septic encephalopathy and establishment of the treatment for septic encephalopathy
| Project/Area Number |
21591998
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Gunma University |
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Principal Investigator |
KADOI Yuji 群馬大学, 医学部, 准教授 (10292591)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 敗血症 / 脳障害 / 海馬 |
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| Research Abstract |
The purpose of this study was to examine the role of NF-κB and AP-1 during septic encephalopathy. After the establishment of septic shock using cecal ligation and puncture rat model, brain was removed. Brain slices were examined by ABC methods. The expression of NF-κB and AP-1 was highly observed in CA-1 region in hippocampus. In addition, response to noxious stimulation was also diminished at the same time. This data indicated that over expression of NF-κB and AP-1 in CA-1 region in hippocampus may have one of important role in the pathogenesis of septic encephalopathy.
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