2011 Fiscal Year Final Research Report
Functional analysis of prostate cancer spheroid forming related genes and its clinical application
| Project/Area Number |
21592034
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Yokohama National University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIRAISHI Taizo 三重大学, 医学系研究科, 教授 (30162762)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 前立腺癌 / スフェロイド / siRNA |
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| Research Abstract |
Some genes including the Plk2were extracted as a candidate gene related with spheroid formation. We analyzed effects of the Plk2on the spheroid characterization and anticancer drug resistance in DU-145 spheroids by suppressing plk2with RNAi. The results indicate that the Plk2may be involved in suppression of tumor growth and acquisition of anticancer drug resistance.
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