2011 Fiscal Year Final Research Report
Development of intracrine androgen deprivation therapy for prostate cancer
| Project/Area Number |
21592035
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
|
| Keywords | 前立腺癌 / アンドロゲン抑制療法 / アンドロゲン代謝 / 細胞内分泌学 |
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| Research Abstract |
The androgen milieu in men with high Gleason score prostate cancer is probably less affected by conventional androgen deprivation therapy than that in men with low score cancer, which was suggested to be associated with adrenal androgen levels. In patients treated with androgen deprivation therapy the pituitary-adrenal axis mediated by adrenocorticotropic hormone、in addition dehydroepiandrosterone-dihydrotestosterone axis has a central role in the regulation of androgen synthesis.
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