2011 Fiscal Year Final Research Report
Identification and translational research of transmenbrane and secretary proteins in prostate cancer
| Project/Area Number |
21592046
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Hiroshima University |
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Principal Investigator |
MATSUBARA Akio 広島大学, 大学院・医歯薬学総合研究科, 教授 (10239064)
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| Co-Investigator(Kenkyū-buntansha) |
YASUI Wataru 広島大学, 大学院・医歯薬学総合研究科, 教授 (40191118)
TEISHIMA Jun 広島大学, 大学院・医歯薬学総合研究科, 講師 (20397962)
INOUE Shogo 広島大学, 病院, 病院助教 (90457177)
HAYASHI Tetsutaro 広島大学, 大学院・医歯薬学総合研究科, 助教 (60612835)
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| Project Period (FY) |
2009 – 2011
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| Keywords | CAST法 / 分泌蛋白 / 前立腺癌 / 膜蛋白 |
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| Research Abstract |
We identified candidate genes that encode transmembrane proteins present in PCa from the screening of Escherichia coli ampicillin secretion trap(CAST) libraries. Further investigations reveled that CDON and NBL1 were expressed much more highly in PCa, suggesting that these molecules have a high potential as a therapeutic target for PCa. Furthermore, we conclude that DSC2 is a useful immunohistochemical marker for separation of squamous differentiation of urothelial carcinoma.
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