Establishment of magnetic field induced interstitial hyperthermic therapy for specific metastatic lesion of prostate cancer using antibody conjugated magnetic nano-partilce

2011 Fiscal Year Final Research Report

• Project/Area Number: 21592055
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: KAWAI Noriyasu 名古屋市立大学, 大学院・医学研究科, 講師 (20254279)
• Co-Investigator(Kenkyū-buntansha): TOZAWA Keiichi 名古屋市立大学, 大学院・医学研究科, 准教授 (40264733) ; HASHIMOTO Yoshihiro 名古屋市立大学, 大学院・医学研究科, 研究員 (40244561) ; ANDO Ryosuke 名古屋市立大学, 大学院・医学研究科, 研究員 (30381867) ; KOHRI Kenjiro 名古屋市立大学, 大学院・医学研究科, 教授 (30122047) ; FUKUTA Katsuhiro 名古屋市立大学, 大学院・医学研究科, 研究員 (30468251) ; IKEGAMI Yosuke 名古屋市立大学, 大学院・医学研究科, 研究員 (40381868)
• Co-Investigator(Renkei-kenkyūsha): KOBAYASHI Takeshi 中部大学, 応用生物学部, 教授 (10043324)
• Project Period (FY): 2009 – 2011
• Keywords: 前立腺癌骨転移 / 磁場誘導組織内加温法 / 抗体結合型磁性ナノ粒子

Research Abstract

(1) Bone invasion model : Interstitial hyperthermia with magnetite demonstrated suppression of bone invasion of prostate cancer.
(2) Prostate membrane specific antigen : The character of anti PMSA antibody was examined. Immunohistochemistry reviled moderate adhesion of anti PMSA antigen to prostate cancer cells.
(3) Manufacturing of anti PMSA antibody-conjugated magnetie : The success rate was low in the making of the AML using PMSA. We should review the form of the magnetite nanoparticle.

Research Products

• [Journal Article] Preoperative Prediction of Neurovascular Bundle Involvement of Localized Prostate Cancer by Combined T2 and Diffusion-weighted Imaging of Magnetic Resonance Imaging, Number of Positive Biopsy Cores, and Gleason Score (2011)
  • Author(s): Naiki T, Okamura T, Nagata D, Mori Y, Kawai N, Ogawa K, Akita H, Hashimoto Y, Tozawa K, Kohri K
  • Journal Title: Asian Pac J Cancer Prev Volume: 12 Pages: 909-13
  • Peer Reviewed
• [Journal Article] Single monthly bacillus Calmette-Guerin intravesical instillation is effective maintenance therapy to prevent recurrence in Japanese patients with non-muscle-invasive bladder cancer (2011)
  • Author(s): Okamura Takehiko, Akita Hidetoshi, Ando Ryosuke, Ikegami Yosuke, Naiki Taku, Kawai Noriyasu, Tozawa Keiichi, Kohri Kenjiro
  • Journal Title: International Journal of Clinical Oncology
  • DOI: DOI:10.1007/s10147-011-0314-3
  • Peer Reviewed
• [Journal Article] Targeted hyperthermia using magnetite cationic liposomes and an alternating magnetic field in a mouse osteosarcoma model (2010)
  • Author(s): Shido Y, Nishida Y. Suzuki Y, Kobayashi T, Ishiguro N
  • Journal Title: J Bone Joint Surg Br Volume: 92 Pages: 580-585
  • Peer Reviewed
• [Presentation] 前立腺癌に対する強度変調放射線治療(IMRT)における内分泌療法併用の意義 (2011)
  • Author(s): 河合憲康、小林大地、内木拓、山田健司、安藤亮介、福田勝洋、池上要介、金本一洋、秋田英俊、岡村武彦、戸澤啓一、芝本雄太、郡健二郎
  • Organizer: 第49回日本癌治療学会学術集会
  • Place of Presentation: 名古屋市
  • Year and Date: 20111027-29
• [Presentation] 前立腺癌骨転移巣に対する温熱治療に向けた基礎研究:ラット前立腺癌大腿骨浸潤モデルの開発 (2011)
  • Author(s): 河合憲康、小林大地、佐藤慎也、小林猛、内木拓、成山泰道、橋本良博、戸澤啓一、佐々木昌一、林祐太郎、白井智之、郡健二郎
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 名古屋市
  • Year and Date: 20110421-24