2011 Fiscal Year Final Research Report
A study on changes of microcirculation of the bladder wall caused by bladder outlet obstruction and effects of alpha adrenoceptor antagonists on impaired bladder microcirculation
| Project/Area Number |
21592070
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya University |
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Principal Investigator |
GOTOH Momokazu 名古屋大学, 大学院・医学系研究科, 教授 (10186900)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Yokunori (20182636)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 下部尿路閉塞 / 膀胱機能障害 / 膀胱微小循環 / 膀胱血流 / 交感神経α1遮断薬 / 膀胱虚血再灌流 / 膀胱過伸展 / 前立腺肥大症 |
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| Research Abstract |
A bladder over-distension model, an ischemia-reperfusion model and a bladder outlet obstruction(BOO) model were created in rats, and microcirculation of the bladder wall was evaluated in those model rats using a pencil lens charge-coupled device microscopy system. In addition, the effect of sympathetic alpha-1 adrenoceptor(AR) antagonists on bladder microcirculation was assessed. From the results of the present study, it is suggested that bladder dysfunction occurs by an impairment of blood flow and ischemia-reperfusion injury in bladder outlet obstruction due to benign prostatic hyperplasia. Sympathetic alpha-1A AR antagonist will improve the bladder function by protecting the impairment of blood flow and ischemia-reperfusion injury.
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