2012 Fiscal Year Final Research Report
establishment of model mouse getting endometrial cancer utilizing the biological difference between estrogen and tamoxifen
| Project/Area Number |
21592119
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tohoku University |
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Principal Investigator |
NIIKURA Hitoshi 東北大学, 大学院・医学系研究科, 准教授 (80261634)
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| Co-Investigator(Kenkyū-buntansha) |
NAGASE Satoru 東北大学, 病院, 准教授 (00292326)
YOSHINAGA Kousuke 東北大学, 大学院・医学系研究科, 非常勤講師 (40343058)
OTSUKI Takeo 東北大学, 大学院・医学系研究科, 非常勤講師 (40531330)
KAIHO Michiko (SAKUMA Michiko) 東北大学, 病院, 助教 (50531331)
SAITO Sumika 東北大学, 病院, 准教授 (60509595)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 子宮内膜癌 / タモキシフェン / 発癌 |
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| Research Abstract |
The influence of tamoxifen (4-HT) to uterus was examined using C57/B6 mouse. By adding tamoxifen, the weight of uterus significantly increased in comparison with control group. Moreover, endometrial glands were enlarged and increasing, and the stroma had edematous change. The growth of Ishikawa was inhibited by STS inhibitor.
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[Journal Article] Clinical outcome of pelvic exenteration in patients with advanced or recurrent uterinecervical cancer2013
Author(s)
Tanaka S, Nagase S, Kaiho-Sakuma M, Nagai T, Kurosawa H, Toyoshima M, Tokunaga H, Otsuki T, Utsunomiya H, Takano T, Niikura H, Ito K, Yaegashi N
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Journal Title
Int J Clin Oncol
Volume: (in press)
URL
Peer Reviewed
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[Journal Article] Small cell carcinoma of the uterine cervix: clinical outcome of concurrent chemoradiotherapy with a multidrug regimen2013
Author(s)
Tokunaga H, Nagase S, Yoshinaga K, Tanaka S, Nagai T, Kurosawa H,Kaiho-Sakuma M, Toyoshima M, Otsuki T, Utsunomiya H, Takano T, Niikura H, Ito K, Yaegashi N
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Journal Title
Tohoku J Exp Med
Volume: 229(1)
Pages: 75-81
URL
Peer Reviewed
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[Journal Article] Individualized radical hysterectomy procedure using intraoperative electricalstimulation for patientswith cervical cancer2012
Author(s)
Nagai T, Niikura H, Kurosawa H, Tanaka S, Otsuki T, Utunomiya H, Nagase S, Takano T, Ito K, Kaiho Y, Nakagawa H, Arai Y, Yaegashi N
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Journal Title
Int J Gynecol Cancer
Volume: 22(9)
Pages: 1591-1596
DOI
Peer Reviewed
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[Journal Article] Malignant transformation arising from mature cystic teratoma of the ovary: a retrospective study of 20 cases2010
Author(s)
Sakuma M, Otsuki T, Yoshinaga K, Utsunomiya H, Nagase S, Takano T, Niikura H, Ito K, Otomo K, Tase T,Watanabe Y, Yaegashi N
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Journal Title
Int J Gynecol Cancer
Volume: 20(5)
Pages: 766-771
URL
Peer Reviewed
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[Journal Article] Case-control study of green tea consumption and the risk of endometrial endometrioid adenocarcinoma2009
Author(s)
Kakuta Y, Nakaya N, Nagase S, Fujita M, Koizumi T, Okamura C, Niikura H, Ohmori K, Kuriyama S, Tase T, Ito K, Minami Y, Yaegashi N, Tsuji I
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Journal Title
Cancer Causes Control
Volume: 20
Pages: 617-624
DOI
Peer Reviewed
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[Journal Article] Roles of intrinsic angiogenesis inhibitor, vasohibin, in cervical carcinomas
Author(s)
Yoshinaga K, Ito K, Moriya T, Nagase S, Takano T, Niikura H, Sasano H, Yaegashi N, Sato Y
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Journal Title
Cancer Science
Volume: 102
Pages: 446-451
DOI
Peer Reviewed
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