2011 Fiscal Year Final Research Report
Analysis of regulation of the inducible nitric oxide synthase geneby estrogen receptor alpha and beta
| Project/Area Number |
21592121
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Toshifumi 山形大学, 医学部, 講師 (20302292)
KURACHI Hirohisa 山形大学, 医学部, 教授 (40153366)
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| Project Period (FY) |
2009 – 2011
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| Keywords | エストロゲン / エストロゲン受容体 / 血管平滑筋 / 誘導型NO合成酵素 / 転写因子 |
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| Research Abstract |
We investigated the effects of dienogest (DNG), which has a profile similar to that of natural progesterone (P4) on the favorable effects of estrogen in endothelial function. Human umbilical vein endothelial cells were treated with medroxyprogesterone acetate (MPA), DNG, or P4 with or without estradiol (E2), and then we examined nitric oxide (NO) production. Although MPA attenuated E2-induced NO production, neither DNG nor P4 inhibited E2 effects. These results suggest that DNG did not inhibit the restoration of vasodilatation by E2. DNG may have an advantage compared with MPA on the endothelial function in postmenopausal women receiving hormone therapy.
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