2011 Fiscal Year Final Research Report
Vasohibin, a novel regulator of angiogenesis, as a useful for molecular targeted therapy and gene therapy in gynecologic malignancies
| Project/Area Number |
21592143
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
SAGA Yasushi 自治医科大学, 医学部, 講師 (70360071)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 卵巣がん / 子宮体がん / 分子標的治療 / 遺伝子治療 / 腫瘍血管新生 / バソヒビン / アデノ随伴ウイルスベクター |
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| Research Abstract |
We showed that vasohibin-1(VASH1), a novel regulator of angiogenesis discovered in this country, can control tumor growth through inhibition of angiogenesis in various gynecologic malignancies. Moreover, we established an adeno-associated virus vector which carries VASH1.These results suggest the possibility of molecular targeted therapy and gene therapy in gynecologic malignancies using VASH1.
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