2011 Fiscal Year Final Research Report
Analysis of immunosuppressive microenvironment associated with Epithelial-Mesenchymal Transition in uterine cancer.
| Project/Area Number |
21592144
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAKAMI Yutaka 慶應義塾大学, 医学部, 教授 (50161287)
AOKI Daisuke 慶應義塾大学, 医学部, 教授 (30167788)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 癌 / 子宮体癌 / 子宮頚癌 / EMT |
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| Research Abstract |
To analyze immunosuppressive tumor microenvironment associated with EMT, novel cancer-associated genes MYEOV and HOXD9 were investigated. After the transfection of MYEOV siRNA into the endometrial cancer cell lines, migration index and invasion index were both significantly lower than that in the control group. mRNA expression of Snail1, Snail2, ZEB1 was significantly reduced, while fibronectin was significantly increased. Silencing of HOXD9 inhibits cell proliferation in 4 of 4 cervical cancer cells, but there were no EMT related gene that was commonly inhibited nor stimulated in 4 cervical cell lines.
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