2011 Fiscal Year Final Research Report
Cytomeagalovirus-induced sensorineural hearing loss in murine model
| Project/Area Number |
21592162
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
OGAWA Hiroshi 福島県立医科大学, 医学部, 准教授 (70264554)
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| Co-Investigator(Renkei-kenkyūsha) |
錫谷 達夫 福島県立医科大学, 医学部, 教授 (40196895)
松井 隆道 福島県立医科大学, 医学部, 助教 (40404876)
生田 和史 福島県立医科大学, 医学部, 助教 (60512184)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ウイルス難聴 / 先天性難聴 / 難聴モデル / マウスサイトメガロウイルス |
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| Research Abstract |
Congenital cytomegalovirus(CMV) infection is the leading of sensorineural hearing loss(SNHL) in children. While the importance of CMV-induced SNHL has been described, the mechanisms surrounding its pathogenesis and the role of inflammatory responses remain unclear. This study presents a neonatal mouse model of profound SNHL caused by directly injecting the virus into cerebral ventricles. Infected cells were detected in the spiral ganglion neurons in immunostain. But after 2 weeks the infected cells were not detected in the infected mice. No significant inflammatory changes in the cochleae of the mice were observed under the light microscope analysis. The question remains why the CMV-related hearing loss is progressive in this murine model.
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[Journal Article] 障害の評価と補聴器・人工内耳の適応2010
Author(s)
小川洋, 馬場陽子, 山田奈保子, 鈴木雪恵, 松井隆道, 野本美香, 小針香菜, 鈴木綾, 村岡理恵, 佐場野優一, 大森孝一
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Journal Title
音声言語医学
Volume: 51(2)
Pages: 199-202
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