A study of a novel allergic rhinitis treatment using nerve repulsion factor semaphorin 3A(Sema3A)

2011 Fiscal Year Final Research Report

• Project/Area Number: 21592179
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kyorin University (2011); Juntendo University (2009-2010)
• Principal Investigator: YOKOI Hidenori 杏林大学, 医学部, 准教授 (80317487)
• Co-Investigator(Kenkyū-buntansha): YOSHITAKE Hiroshi 順天堂大学, 医学部, 助教 (00396574)
• Project Period (FY): 2009 – 2011
• Keywords: 神経反発因子 / セマフォリ3A / アレルギー性鼻炎 / 鼻粘膜過敏症

Research Abstract

Semaphorin 3A(Sema3A), a nerve repulsion factor, has been reported to be specifically associated with a role in chronic inflammation of the nerves(i. e., in cases of nasal mucosal hypersensitivity), but not in allergic inflammation in the human nasal mucosa.

Research Products

• [Journal Article] Tonsillar TLR9 expression and efficacy of tonsillectomy with steroid pulse therapy in IgA nephropathy patients (2012)
  • Author(s): Sato D, Suzuki Y, Kano T, Suzuki H, Matsuoka J, Yokoi H, Horikoshi S, Ikeda K, Tomino Y
  • Journal Title: Nephrol Dial Transplant Volume: 27 Pages: 1090-1097
• [Journal Article] Heme oxygenase-1 expression in chronic rhinosinusitis with eosinophilic infiltration (2011)
  • Author(s): Kawano K, Kusunoki T, Ono N, Yao T, Saito T, Yokoi H, Ikeda K
  • Journal Title: Auris Nasus Larynx Volume: 39 Pages: 387-392
• [Journal Article] An immunohistochemical study of sinonasal hemangiopericytoma (2011)
  • Author(s): Yokoi H, Arakawa A, Kuribayashi K, Inoshita A, Haruyama T, Ikeda K
  • Journal Title: Auris Nasus Larynx Volume: 38 Pages: 743-6
• [Journal Article] An inflammatory calcified nodule in the buccal subcutis-A case report (2011)
  • Author(s): Yokoi H, Yoshikawa H, Matsumoto T, Kawano K, Ikeda K
  • Journal Title: B-ENT Volume: 7(3) Pages: 215-8
• [Journal Article] Bacteriology of recurrent exacerbation of postoperative course in chronic rhinosinusitis in relation to asthma (2011)
  • Author(s): Ikeda K, Yokoi H, Kusunoki T, Saitoh T, Yao T, Kase K, Minekawa A, Inoshita A, Kawano K
  • Journal Title: Auris Nasus Larynx Volume: 38 Pages: 469-73
• [Journal Article] Relationship between olfactory acuity and peak expiratory flow during postoperative follow-up in chronic rhinosinusitis associated with asthma (2010)
  • Author(s): Ikeda K, Yokoi H, Kusunoki T, Saito T, Yao T, Kase K, Minekawa A, Inoshita A, Kawano K
  • Journal Title: Ann Oto Rhinol Laryngol Volume: 119 Pages: 749-754
• [Journal Article] Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells (2010)
  • Author(s): Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K
  • Journal Title: J Immunol Volume: 184 Pages: 3526-34
• [Journal Article] Role of interleukin-17A in the eosinophil accumulation and mucosal remodeling in chronic rhinosinusitis. with nasal polyps associated with asthma (2010)
  • Author(s): Saitoh T, Kusunoki T, Yao T, Kawano K, Kojima Y, Miyahara K, Onoda J, Yokoi H, Ikeda K
  • Journal Title: Int Arch Allergy Immunol Volume: 151 Pages: 8-16
• [Journal Article] Oral levofloxacin vs intravenous flomoxef prophylaxis in postoperative infection after endoscopic sinus surgery (2009)
  • Author(s): Inoshita A, Yokoi H, Matsumoto F, Yao T, Kawano K, Furukawa M, Ikeda K
  • Journal Title: Am J Otolaryngol Volume: 31 Pages: 360-363
• [Journal Article] Bacterial contamination of Multiple-use atomizers commonly used in Japan (2009)
  • Author(s): Ikeda K, Sakai Y, Haruyama T, Misawa N, Misawa N, Hori S, Kusunoki T, Furukawa M, Yokoi H, Yokoi N, Ichihari Y, Kawano K, Matsumoto F, Hayashi C, Narui Y, Iizuka T, Ito S, Inoshita A, Kasai M, Saito T, Minekawa A, Oba S, Cho Y
  • Journal Title: Indian J Otolaryngol Head Neck Surg. Volume: 61 Pages: 193-6
• [Journal Article] Relationship between epithelial damage or basement membrane thickness and eosinophilic infiltration in nasal polyps with chronic rhinosinusitis (2009)
  • Author(s): Saitoh T, Kusunoki T, Yao T, Kawano K, Kojima Y, Miyahara K, Onoda J, Yokoi H, Ikeda K
  • Journal Title: Rhinology Volume: 47 Pages: 275-9
• [Journal Article] Prevention of ultrasonic coagulator-mediated mucoperiosteal flap injury and defects by using a clip manipulation in the resection of the posterior nasal nerve (2009)
  • Author(s): Ikeda K, Yokoi H, Saito T, Kawano K, Yao T, Furukawa M, Kusunoki T
  • Journal Title: Rhinology Volume: 47 Pages: 45-7
• [Journal Article] Eotaxin-1,-2 and-3 immunoreactivity and protein concentration in the nasal polyps of eosinophilic chronic rhinosinusitis patients (2009)
  • Author(s): Yao T, Kojima Y, Koyanagi A, Yokoi H, Saito T, Kawano K, Furukawa M, Kusunoki T, Ikeda K
  • Journal Title: Laryngoscope Volume: 119 Pages: 1053-1059
• [Journal Article] Inhibitory action of roxithromycin on histamine release. and prostaglandin D2 production from beta-defensin 2-stimulated mast cells (2009)
  • Author(s): Kase K, Hua J, Yokoi H, Ikeda K, Nagaoka I
  • Journal Title: Int J Mol Med Volume: 23 Pages: 337-40
• [Journal Article] Biopsy of cervical lymph node (2009)
  • Author(s): Matsumoto F, Itoh S, Ohba S, Yokoi H, Furukawa M, Ikeda K
  • Journal Title: Auris Nasus Larynx Volume: 36 Pages: 71-74
• [Presentation] Schwannoma of the nasal septum associated with multiple central nerve system tumors which was totally resected endoscopically (2011)
  • Author(s): Hidenori Yokoi, Ryouta Yoshii, Satoshi Tsutsumi, Naoyuki Kohno
  • Organizer: XIV IRS & XXX ISIAN
  • Year and Date: 20110920-23