2011 Fiscal Year Final Research Report
Expression and clinical analysis of a novel cancer/testis antigen, TEX101 in head and neck squamous cell carcinoma
| Project/Area Number |
21592206
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ARAKI Yoshihiko 順天堂大学, 医学研究科, 准教授 (70250933)
YOKOI Hidenori 杏林大学, 医学部, 准教授 (80317487)
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| Project Period (FY) |
2009 – 2011
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| Keywords | TEX101 / 癌・精巣抗原 / 頭頸部癌 / GPIアンカー型タンパク質 |
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| Research Abstract |
A germ cell-marker glycoprotein, TEX101 is expressed not only in germ cells but also in cancer cells from patients with head and neck squamous cell carcinoma, demonstrating that this molecule is a novel cancer/testis antigen. The rate of lymph nodes metastasis tends to be low in the TEX101-positive HNSCC patients, compared to the patients with cancer of weak positive and negative expression of TEX101. TEX101 may be useful as a biological marker and a target for cancer therapy.
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