2011 Fiscal Year Final Research Report
Regulation of angiostatic factors for diabetic macular edema
| Project/Area Number |
21592234
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Nagasaki University |
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Principal Investigator |
SUZUMA Kiyoshi 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (80335265)
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| Co-Investigator(Kenkyū-buntansha) |
KITAOKA Takashi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (80234235)
FUJIKAWA Azusa 長崎大学, 病院, 講師 (60363503)
TUIKI Eiko 長崎大学, 大学院・医歯薬学総合研究科, 助教 (30363493)
MATSUMOTO Makiko 長崎大学, 病院, 助教 (70437903)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 糖尿病網膜症 / VEGF / エリスロポエチン / コハク酸 |
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| Research Abstract |
In proliferative diabetic retinopathy, levels of succinate increased significantly. However, in proliferative diabetic retinopathy after anti-VEGF therapy, levels of succinate decreased significantly. Since it has been previously reported that succinate induces VEGF expression, a positive feedback mechanism from VEGF to succinate was suggested. These data were novel findings.
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Research Products
(10 results)
