2011 Fiscal Year Final Research Report
Development of the new treatment strategy through the TRP channel to severe neurotrophic keratopathy and alkali burn in cornea
| Project/Area Number |
21592241
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Wakayama Medical University |
|---|
Principal Investigator |
OKADA Yuka 和歌山県立医科大学, 医学部, 講師 (50264891)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SAIKA Shizuya 和歌山県立医科大学, 医学部, 教授 (40254544)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 角膜 / 創傷治癒 / TRPチャンネル |
|---|
| Research Abstract |
Absence or blocking TRP channels suppressed inflammation and fibrosis/sacrring during healing of alkali-burnec cornea. Systemic TRP channel antagonists reproduced the KO-type of healing. In conclusion, absence or blocking of TRPV1 suppressed inflammation and fibrosis/scarring during healing of severe neurotrophic keratopaty and alkali burn in cornea.
|
