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2011 Fiscal Year Final Research Report

Application to the clarification and treatment of endoplasmic reticulum stress related the retinal pigment epithelium cells in Age-related macular degeneration.

Research Project

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Project/Area Number 21592251
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionKansai Medical University

Principal Investigator

TAKAHASHI Kanji  関西医科大学, 医学部, 教授 (60216710)

Co-Investigator(Kenkyū-buntansha) OGATA Nahoko  関西医科大学, 医学部, 准教授 (60204062)
ANDO Akira  関西医科大学, 医学部, 講師 (50319612)
Project Period (FY) 2009 – 2011
Keywords小胞体ストレス / 加齢黄斑変性 / 網膜色素上皮 / Tight junction
Research Abstract

The endoplasmic reticulum(ER) is an important intracellular organelle responsible for the biosynthesis and folding of proteins. It has been reported that ER stress has been linked to the diabetic retinopathy and age-related macular degeneration(AMD). Increased protein expressions and transepithelial electrical resistance of tight junctions by ER stress in RPE cells indicate that ER stress can alter the function of RPE cells and may be involved in the pathogenesis of AMD.

  • Research Products

    (17 results)

All 2011 2010 2009

All Journal Article (12 results) (of which Peer Reviewed: 7 results) Presentation (4 results) Book (1 results)

  • [Journal Article] Increased expression of tight junctions in ARPE-19 cells under endoplasmic reticulum stress2011

    • Author(s)
      Yoshikawa T, Ogata N, Izuta H, Shimazawa M, Hara H, Takahashi K
    • Journal Title

      Curr Eye Res

      Volume: 36(12) Pages: 1153-63

    • Peer Reviewed
  • [Journal Article] Characteristics of age-related macular degeneration in patients with diabetic retinopathy2011

    • Author(s)
      Yoshikawa T, Ogata N, Wada M, Otsuji T, Takahashi K
    • Journal Title

      Jpn J Ophthalmol

      Volume: 55(3) Pages: 235-240

    • Peer Reviewed
  • [Journal Article] Effects of intravitreally injected bevacizumab on vascular endothelian growth factor in fellow eyes2011

    • Author(s)
      Matsuyama K, Ogata N, Matsuoka M, Wada M, Nishimura T, Takahashi K
    • Journal Title

      J Ocul Pharmacol

      Volume: 55(4) Pages: 502-505

    • Peer Reviewed
  • [Journal Article] 網膜血管腫状増殖を合併した網膜色素変性の1例2011

    • Author(s)
      長央由里子、平本裕盛、高橋寛二
    • Journal Title

      日眼会誌

      Volume: 115(2) Pages: 139-143

    • Peer Reviewed
  • [Journal Article] ラニビズマブ硝子体内注射における反応不良例の検討2011

    • Author(s)
      正健一郎、尾辻剛、津村晶子、津田メイ、高橋寛二
    • Journal Title

      眼臨紀

      Volume: 4(8) Pages: 782-784

    • Peer Reviewed
  • [Journal Article] 加齢黄斑変性の分類と診断2011

    • Author(s)
      高橋寛二
    • Journal Title

      あたらしい眼科

      Volume: 28(20) Pages: 157-163

  • [Journal Article] 網膜血管腫状増殖2011

    • Author(s)
      高橋寛二
    • Journal Title

      臨眼

      Volume: 65(増) Pages: 274-281

  • [Journal Article] 加齢黄斑変性の治療指針2011

    • Author(s)
      高橋寛二
    • Journal Title

      Geriat Med

      Volume: 49(4) Pages: 379-383

  • [Journal Article] Plasma levels of vascular endothelial growth factor and pigment epithelium-derived factor before and after intravitreal injection of bevacizumab2010

    • Author(s)
      Matsuyama K, Ogata N, Matsuoka M, Wada M, Takahashi K, Nishimura T
    • Journal Title

      Br J Ophthalmol

      Volume: 94(9) Pages: 1215-1218

    • Peer Reviewed
  • [Journal Article] 滲出型加齢黄斑変性におけるスペクトラルドメインOCT所見2010

    • Author(s)
      永井由巳、有澤章子、正健一郎、尾辻剛、西川真生、津村晶子、久保木香織、長央由里子、高橋寛二
    • Journal Title

      眼科臨床紀要

      Volume: 3(8) Pages: 804-811

    • Peer Reviewed
  • [Journal Article] 加齢黄斑変性-治療の進歩2010

    • Author(s)
      高橋寛二
    • Journal Title

      綜合臨床

      Volume: 59(7) Pages: 1633-1634

  • [Journal Article] 加齢黄斑変性の新しい分類と診断基準2009

    • Author(s)
      高橋寛二
    • Journal Title

      眼科手術

      Volume: 22(3) Pages: 333-336

  • [Presentation] 加齢黄斑変性の治療指針2011

    • Author(s)
      高橋寛二, ほか
    • Organizer
      日本臨床眼科学会
    • Place of Presentation
      東京
    • Year and Date
      20111007-10
  • [Presentation] 小胞体ストレスを高濃度もしくは長時間暴露時のtight junctionの変化2011

    • Author(s)
      吉川匡宣、高橋寛二, ほか
    • Organizer
      日本眼科学会
    • Place of Presentation
      東京
    • Year and Date
      20110512-15
  • [Presentation] Altered expression of tight junctions in APRE19 cells under endoplasmic reticulum stress2010

    • Author(s)
      吉川匡宣、高橋寛二, ほか
    • Organizer
      The Association for Research in Visual Science and Ophthalmology
    • Place of Presentation
      アメリカ
    • Year and Date
      20100502-06
  • [Presentation] 小胞体ストレス負荷時の網膜色素上皮細胞におけるtight junctionの変化2010

    • Author(s)
      吉川匡宣、高橋寛二, ほか
    • Organizer
      日本眼科学会
    • Place of Presentation
      東京
    • Year and Date
      20100415-18
  • [Book] 脈絡膜新生血管、病気の分子形態学2011

    • Author(s)
      高橋寛二
    • Total Pages
      357-360
    • Publisher
      学際企画

URL: 

Published: 2013-07-31  

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