Roles of macrophages in the development of allergic conjunctival diseases

2011 Fiscal Year Final Research Report

• Project/Area Number: 21592259
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kochi University
• Principal Investigator: FUKUSHIMA Atsuki 高知大学, 教育研究部・医療学系, 教授 (40281737)
• Project Period (FY): 2009 – 2011
• Keywords: アレルギー / 結膜 / 抗原提示細胞 / FcεRIα / 好塩基球 / T細胞 / マクロファージ / 好酸球

Research Abstract

Vernal keratoconjunctivitis(VKC) is a severe form of allergic conjunctival diseases and may lead to blindness. VKC is an antigen-specific disease and antigen-presenting cels play crucial roles in its development. During this research period, we found that basophils are exerting antigen-presenting capability in allergic conjunctival diseases.

Research Products

• [Journal Article] Adjuvants determine the contribution of basophils to antigen sensitization in vivo (2011)
  • Author(s): Ishida W, Fukuda K, Sumi T, Ebihara N, Kajisako M, Matsuda H, Yagita H, Fukushima A
  • Journal Title: Immunol Lett Volume: 136 Pages: 49-54
  • Peer Reviewed
• [Journal Article] Participation of CD11b and F4/ 80 molecules in the conjunctival eosinophilia of experimental allergic conjunctivitis (2010)
  • Author(s): Fukushima A, Ishida W, Ojima A, Kajisako M, Sumi T, Yamada J, Tsuru E, Miyazaki J-i, Tominaga A, Yagita H
  • Journal Title: Int Arch Allergy Immunol Volume: 151(2) Pages: 129-136
  • Peer Reviewed
• [Journal Article] Conjunctival macrophages act as antigen-presenting cells in the conjunctiva during the development of experimental allergic conjunctivitis (2010)
  • Author(s): Ishida W, Kajisako M, Takahashi A, Sumi T, van Rooijen N, Fukuda K, Fukushima A
  • Journal Title: Mol Vision Volume: 16 Pages: 1280-1285
  • Peer Reviewed