Cytokine profile in biliary atresia patients

2011 Fiscal Year Final Research Report

• Project/Area Number: 21592273
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatric surgery
• Research Institution: Chiba University
• Principal Investigator: SAITO Takeshi 千葉大学, 医学部・附属病院, 講師 (20406044)
• Co-Investigator(Kenkyū-buntansha): YOSHIDA Hideo 千葉大学, 大学院・医学研究院, 教授 (60210712) ; HISHIKI Tomoro 千葉大学, 大学院・医学研究院, 講師 (00375776) ; MITUNAGA Tetsuya 千葉大学, 医学部附属病院, 助教 (80375774) ; NAKATA Mituyuki 千葉大学, 医学部附属病院, 助教 (90375775) ; SATO Yoshiharu 千葉大学, 医学部附属病院, 助教 (60375772) ; TERUI Keita 千葉大学, 医学部附属病院, 助教 (70375773)
• Project Period (FY): 2009 – 2011
• Keywords: 先天性消化器疾患学 / 胆道閉鎖症 / サイトカイン / サイトカインネットワーク / 自然免疫

Research Abstract

Using the serum and liver specimens taken from biliary atresia (BA)patients around the operation, we investigated both the systemic and local immunological environment of BA. It was suggested the significant difference between Th1 and Th2 cytokines expression levels has not been found in the systemic immunity. However, the representative local environment in the liver showed Th1 polarization.

Research Products

• [Journal Article] Hepatic expression of multidrug resistance protein 2 in biliary atresia (2011)
  • Author(s): Terui K, Saito T, Hishiki T, Sato Y, Mitsunaga T, Yoshida H
  • Journal Title: Comp Hepatol Volume: 10 Pages: 6
  • Peer Reviewed
• [Journal Article] Use of preoperative, 3-dimensional magnetic resonance cholangiopancreatography in pediatric choledochal cysts (2011)
  • Author(s): Saito T, Hishiki T, Terui K, Sato Y, Mitsunaga T, Terui E, Nakata M, Takenouchi A, Matsuura G, Yahata E, Ohno S, Sato H, Yanagawa N, Masuda Y, Yoshida H
  • Journal Title: Surgery Volume: 149 Pages: 569-75
  • DOI: DOI:10.1097/MPG.0b013e3182307c9c
  • Peer Reviewed
• [Journal Article] Toll-like receptor mRNA expression in liver tissue from biliary atresia patients Nutr (2011)
  • Author(s): Saito T, Hishiki T, Terui K, Mitsunaga T, Terui E, Nakata M, Yoshida H
  • Journal Title: J Pediatr Gastroenterol Volume: 53 Pages: 620-6
  • DOI: DOI:10.1016/j.surg.2010.11.004
  • Peer Reviewed
• [Journal Article] Living-donor liver transplantation in 126 patients with biliary atresia : single-center experience (2010)
  • Author(s): Mizuta K, Sanada Y, Saito T, Kawarasaki H
  • Journal Title: Transplant Proc Volume: 42 Pages: 4127-31
  • Peer Reviewed
• [Journal Article] Expression level of Toll-like receptor mRNA in liver tissue from patients with biliary atresia. In : Matsui A, editor. Biliary Atresia (2009)
  • Author(s): Saito T, Hishiki T, Terui K, Sato Y, Takenouchi A, Yahata E, Ono S, Yoshida H
  • Journal Title: 1^<st> ed. Tokyo Tokyoinshokan Pages: 22-25
  • Peer Reviewed
• [Presentation] Toll-like receptor mRNA expression in liver tissue from biliary atresia patients (2011)
  • Author(s): Saito T, Hishiki T, Sato Y, Mitsunaga T, Terui E, Saito E, Yoshida H
  • Organizer: International Surgical week/ISW 2011
  • Place of Presentation: 横浜
  • Year and Date: 2011-08-31
• [Presentation] 胆道閉鎖症における血中サイトカイン解析の意義 (2010)
  • Author(s): 齋藤武, 菱木知郎, 照井慶太, 佐藤嘉治, 光永哲也, 松浦玄, 八幡江里子, 三瀬直子, 柴田涼平, 坂本明美, 幡野雅彦, 岩井潤, 東本恭幸, 吉田英生
  • Organizer: 第37回日本胆道閉鎖症研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-12-11
• [Presentation] 胆道閉鎖症における血中サイトカイン解析の意義 (2010)
  • Author(s): 齋藤武, 菱木知郎, 照井慶太, 佐藤嘉治, 武之内史子, 八幡江里子, 大野幸恵, 三瀬直子, 吉田英生, 坂本明美, 幡野雅彦, 岩井潤, 東本恭幸, 光永哲也
  • Organizer: 第47回日本小児外科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-06-17
• [Presentation] 生後40日以内に根治術を施行された胆道閉鎖症の転帰 (2010)
  • Author(s): 齋藤武, 菱木知郎, 佐藤嘉治, 光永哲也, 照井エレナ, 松浦玄, 柴田涼平, 吉田英生
  • Organizer: 第106回東京小児外科
  • Place of Presentation: 東京
  • Year and Date: 2010-06-01
• [Book] 成長障害 (2010)
  • Author(s): 齋藤武
  • Total Pages: 220-222