2011 Fiscal Year Final Research Report
Basic studies regarding the usefulness of STEP procedure in short bowel syndrome
| Project/Area Number |
21592277
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | University of Tsukuba (2011)
Fukuoka University (2009-2010) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAGUCHI Tomoaki 九州大学, 医学研究院, 教授 (20197247)
NAKAMURA Masatoshi 福岡大学, 医学部, 助教 (10580285)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 短腸症候群 / 小児 / 腸管延長術 / 有用性 / 腸閉鎖症 |
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| Research Abstract |
The rat neonatal short bowel syndrome (SBS) model related to intestinal atresia was made at first. STEP (Serial Transverse Enteroplasty) procedure was performed for the SBS rat model one month after short bowel was made. The chronological changes of intramural components in dilated intestine after STEP procedure was investigated and compared using immunohistological staings between SBS-STEP models and SBS models. The results showed the abnormal change of intramural components (ganglion cells, nerve fibers, smooth muscle cells, and pacemaker cells) relatively improved in SBS-STEP models, compared to those in SBS models. Therefore, based on our studies, the early STEP procedure, performing before the proximal dilatation will be extremely, might induce the early improvement of the intramural abnormal changes in SBS.
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