2011 Fiscal Year Final Research Report
Molecular dissection of transcription factor on bone formation
| Project/Area Number |
21592356
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
KAWAI Shinji 大阪大学, 大学院・歯学研究科, 特任准教授 (40362678)
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| Co-Investigator(Kenkyū-buntansha) |
AMANO Atsuo 大阪大学, 大学院・歯学研究科, 教授 (50193024)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 口腔生化学 |
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| Research Abstract |
To elucidate the in vivo function of Osr1, we generated transgenic mice overexpressing Osr1. Osr1 transgenic mice demonstrated delayed cranial sutures. Examinations of newborn Osr1 transgenic mice skeletons stained with alcian blue and alizarin red showed abnormalities in the skull and skeletal elements. Calvarial osteoblasts obtained from Osr1 transgenic mice showed abnormalities in osteoblast differentiation and proliferation, confirming that Osr1 is required for osteogenesis. Our genetic observations showed that the Osr1 gene plays a key role in osteoblastic cell proliferation.
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