2011 Fiscal Year Final Research Report
Role of Mcl-1 expression on tumor cell growth and metastasis
| Project/Area Number |
21592357
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
WADA Koichiro 大阪大学, 大学院・歯学研究科, 准教授 (90263467)
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| Co-Investigator(Kenkyū-buntansha) |
KAMISAKI Yoshinori 大阪大学, 大学院・歯学研究科, 教授 (40116017)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 核内受容体 / Mcl-1 / 扁平上皮癌 / アノイキス / 浸潤 |
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| Research Abstract |
Myeloid cell leukemia-1(Mcl-1), a member of the B-cell lymphoma-2(Bcl-2) family, has been reported to be a critical survival factor in hematopoietic cells, yet little data exists for a role of Mcl-1 in human squamous cell carcinoma(SCC). A high level expression of Mcl-1 was observed in tumor cells of human primary SCC, lymph node metastasis tissues, and SCC cell lines. We observed that Mcl-1 siRNA inhibited the growth of SCCs accompanied with apoptosis. We also observed the involvement of aquaporin 3 on the growth of SCCs. These results imply a potentially important and novel role of the inhibition of Mcl-1 or aquaporin 3 by the use of specific siRNA in the treatment of SCC.
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Author(s)
Kojima A, Nakano K, Wada K, Takahashi H, Katayama K, Yoneda M, Higurashi T, Nomura R, Hokamura K, Muranaka Y, Matsuhashi N, Umemura K, Kamisaki Y, Nakajima A, Ooshima T.
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Journal Title
Scientific Reports
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Pages: 332
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Nakano K, Hokamura K, Taniguchi N, Wada K, Kudo C, Nomura R, Kojima A, Naka S, Muranaka Y, Thura M, Nakajima A, Masuda K, Nakagawa I, Speziale P, Shimada N, Amano A, Kamisaki Y, Tanaka T, Umemura K, Ooshima T.
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Nature Communications
Volume: 2
Pages: 485
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Journal Title
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Volume: 17
Pages: 370-378
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[Journal Article] Liver abscess caused by periodontal bacterial infection with Fusobacterium necrophorum2011
Author(s)
Yoneda M, Kato S, Mawatari H, Kirikoshi H, Imajo K, Fujita K, Endo H, Takahashi H, Inamori M, Kobayashi N, Kubota K, Saito S, Tohnai I, Watanuki K, Wada K, Maeda S, Nakajima A.
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Journal Title
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Volume: 41
Pages: 194-196
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[Journal Article] Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis2011
Author(s)
Endo H, Hosono K, Uchiyama T, Sakai E, Sugiyama M, Takahashi H, Nakajima N, Wada K, Takeda K, Nakagama H, Nakajima A.
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Journal Title
Gut
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Pages: 1363-1371
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[Journal Article] Role of the long form leptin receptor and of the STAT3 signaling pathway in colorectal cancer progression2011
Author(s)
Uchiyama T, Takahashi H, Endo H, Sugiyama M, Sakai E, Hosono K, Nagashima Y, Inayama Y, Wada K, Hippo Y, Nakajima A.
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Journal Title
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Volume: 39
Pages: 935-940
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Sakuma S, Nishioka Y, Imanishi R, Nishikawa K, Sakamoto H, Fujisawa J, Wada, K, Kamisaki Y, Fujimoto Y.
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Journal Title
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Volume: 47
Pages: 167-173
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[Journal Article] Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary condition2009
Author(s)
Endo H, Hosono K, Fujisawa T, Takahashi H, Sugiyama M, Yoneda K, Nozaki Y, Fujita K, Yoneda M, Inamori M, Wada K, Nakagama H, Nakajima A.
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Journal Title
Gut
Volume: 58
Pages: 1637-16431
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[Journal Article] Influence of iNOS polymorphisms in Japanese patients with nonalcoholic fatty liver disease2009
Author(s)
Yoneda M, Hotta K, Nozaki Y, Endo H, Tomeno W, Watanabe S, Hosono K, Mawatari H, Iida H, Fujita K, Takahashi H, Kirikoshi H, Kobayashi H, Inamori M, Kubota K, Shimamura T, Saito S, Maeyama S, Wada K, Nakajima A.
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Journal Title
Hepatology Research
Volume: 39
Pages: 963-971
Peer Reviewed
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[Journal Article] Association between angiotensin II type1receptor polymorphisms and the occurrence of nonalcoholic fatty liver disease.2009
Author(s)
Yoneda M, Hotta K, Nozaki Y, Endo H, Uchiyama T, Mawatari H, Iida H, Kato S, Fujita K, Takahashi H, Kirikoshi H, Kobayashi N, Inamori M, Abe Y, Kubota K, Saito S, Maeyama S, Wada K, Nakajima A.
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Journal Title
Liver International
Volume: 29
Pages: 1078-1085
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