Involvement of a novel signaling molecule, PRIP in the regulation of bone metabolism through reproduction system

2011 Fiscal Year Final Research Report

• Project/Area Number: 21592365
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Functional basic dentistry
• Research Institution: Kyushu University
• Principal Investigator: MATSUDA Miho 九州大学, 歯学研究院, 助教 (40291520)
• Project Period (FY): 2009 – 2011
• Keywords: 生殖・ホルモン・骨代謝

Research Abstract

This study revealed the following :(i) PRIP was involved in female reproductive system, especially in gonadotropins secretion and ovarian follicle maturation.(ii) The bone mineral density and trabecular bone volume were higher in PRIP-gene deficient mice due to enhanced bone formation and decreased bone resorption, indicating that PRIP is implicated in the negative regulation of bone formation.

Research Products

• [Journal Article] Involvement of PRIP, phospholipase C-related, but catalytically inactive protein (2011)
  • Author(s): Tsutsumi, K., Matsuda, M., Kotani, M., Murakami, A., Mizokami, A., Takahashi, I., Terada, Y., Kanematsu, T., Fukami, K., Takenawa, T., Jimi, E. and Hirata, M.
  • Journal Title: in bone formation. J. Biol. Chem Volume: 286 Pages: 31032-31042
  • Peer Reviewed
• [Journal Article] Assay of dense-core vesicle exocytosis using permeabilized PC12 cells (2010)
  • Author(s): Gao, J., Takeuchi, H., Umebayashi, H., Zhang, Z., Matsuda, M. and Hirata, M.
  • Journal Title: Adv. Enz. Regul Volume: 50 Pages: 237-246
  • Peer Reviewed
• [Journal Article] Involvement of phospholipase C-related inactive protein in the mouse reproductive system through the regulation of gonadotropin levels (2009)
  • Author(s): Matsuda, M, Tsutsumi, K., Kanematsu, T., Fukami, K., Terada, Y., Takenawa, T., Nakayama, K. I., Hirata, M.
  • Journal Title: Biol Reprod Volume: 81 Pages: 681-689
  • Peer Reviewed
• [Presentation] 新規情報伝達分子PRIPノックアウトマウスにおける生殖制御の異常 (2011)
  • Author(s): 松田美穂、平田雅人
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-13
• [Presentation] PRIP is implicated in the negative regulation of bone formation (2011)
  • Author(s): 小谷美穂、堤康史郎、松田美穂、平田雅人
  • Organizer: International Symposium, New Aspects of Phospholipid Biology and Medicine 2011
  • Place of Presentation: 福岡
  • Year and Date: 2011-11-15
• [Presentation] PRIPはautophagyを抑制的に制御する (2011)
  • Author(s): 梅林久範、松田美穂、兼松隆
  • Organizer: 第53回歯科基礎医学会学術大会
  • Place of Presentation: 岐阜
  • Year and Date: 2011-09-30
• [Presentation] PRIP遺伝子欠損マウスで観察された骨の表現型の解析 (2011)
  • Author(s): 堤康史郎、松田美穂、小谷美穂、平田雅人(他)
  • Organizer: 第53回歯科基礎医学会学術大会
  • Place of Presentation: 岐阜
  • Year and Date: 2011-09-30
• [Presentation] Involvement of PRIP in the regulation of bone metabolism (2010)
  • Author(s): 」松田美穂、平田雅人
  • Organizer: 第83回日本生化学会・第33回日本分子生物学会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-09
• [Presentation] The role of PRIP in the regulation of autophagy (2010)
  • Author(s): 梅林久範、松田美穂、兼松隆、平田雅人
  • Organizer: 第12回IUBMB & 第21回FAOBMB(国際生化学分子生物学連合カンファレンス)
  • Place of Presentation: メルボルン
  • Year and Date: 2010-09-30
• [Presentation] 「Regulatory role of PRIP in the bone formation (2010)
  • Author(s): 堤康史郎、松田美穂、自見英治郎、平田雅人
  • Organizer: 第12回IUBMB & 第21回FAOBMB(国際生化学分子生物学連合カンファレンス)
  • Place of Presentation: メルボルン
  • Year and Date: 2010-09-30
• [Presentation] Pituitary and ovarian function in PRIP knockout mice (2010)
  • Author(s): 松田美穂、平田雅人
  • Organizer: 第12回IUBMB & 第21回FAOBMB(国際生化学分子生物学連合カンファレンス)
  • Place of Presentation: メルボルン
  • Year and Date: 2010-09-29
• [Presentation] PRIPは骨形成の制御に関与する (2010)
  • Author(s): 」堤康史郎、松田美穂、平田雅人
  • Organizer: PRIPは骨形成の制御に関与第52回歯科基礎医学会学術大会・総会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-21
• [Presentation] Involvement of PRIP in the regulation of bone metabolism (2009)
  • Author(s): 松田美穂
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-10
• [Presentation] Involvement of PRIP in the reproduction system through the regulation of gonadotropin levels (2009)
  • Author(s): 」松田美穂、平田雅人
  • Organizer: 第6回Japan-Korea Conference on Cellular Signaling for Young Scientists
  • Place of Presentation: 佐世保
  • Year and Date: 2009-11-24
• [Presentation] Involvement of PRIP in the regulation of bone metabolism (2009)
  • Author(s): 堤康史郎、松田美穂、平田雅人
  • Organizer: 第32回日本生化学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-10
• [Presentation] 「PRIPの骨代謝における機能解析 (2009)
  • Author(s): 堤康史郎、松田美穂、平田雅人
  • Organizer: 第51回歯科基礎医学会学術大会・総会
  • Place of Presentation: 最優秀ポスター賞受賞
  • Year and Date: 2009-09-10
• [Presentation] Involvement of a novel inositol 1, 4, 5-trisphosphate binding protein, PRIP, in the reproductive system through the regulation of gonadotropin levels (2009)
  • Author(s): 松田美穂、平田雅人
  • Organizer: 第21回IUBMB & 第12回FAOBMB(国際生化学分子生物学連合カンファレンス)
  • Place of Presentation: 上海
  • Year and Date: 2009-08-06
• [Presentation] 骨形成制御機構におけるPRIPの機能解析
  • Author(s): 小谷美穂、堤康史郎、松田美穂、平田雅人
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都