2011 Fiscal Year Final Research Report

Chronological and morphological analysis of microcirculation in transgenic mouse model with odontogenic cystic les ion.

Research Project

Project/Area Number	21592384
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Pathobiological dentistry/Dental radiology
Research Institution	Tohoku University
Principal Investigator	ONODERA Ken 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (30233597)
Co-Investigator(Kenkyū-buntansha)	KUMAMOTO Hiroyuki 東北大学, 大学院・歯学研究科, 教授 (70215028)
Project Period (FY)	2009 – 2011
Keywords	歯学 / 病理学 / 遺伝子
Research Abstract	Preliminary, we examined jaw cysts in heterozygous ptc knockout mouse. Mandibular cysts were often histologically detected in the alveolar bones or periodontal ligaments of the molars, but maxillary cysts were not detected. And we analyzed the expression of CD31, CD34 and D2-40 in human odontogenic cystic lesions of dentigerous cysts, radicular cysts and keratocystic odontogenic tumors. Distinctly positive staining for D2-40 was found in lymphatic vessels located in the cystic walls. Small blood vessels stained for CD31 and CD34 were also present in the cystic walls. Especially, numerous lymphatic vessels and blood vessels were present in the radicular cysts.